TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
1_MDPTG 6_ SQLDS 11_ DFSQQ 16_ DTPCL 21_ IIEDS 26_ QPESQ 31_ VLEDD 36_ SGSHF 41_ SMLSR 46_ HLPNL 51_ QTHKE 56_ NPVLD 61_ VVSNP 66_ EQTAG 71_ EERGD 76_ GNSGF 81_ NEHLK 86_ ENKVA 91_ DPVDS 96_ SNLDT 101_ CGSIS 106_ QVIEQ 111_ LPQPN 116_ RTSSV 121_ LGMSV 126_ ESAPA 131_ VEEEK 136_ GEELE 141_ QKEKE 146_ KEEDT 151_ SGNTT 156_ HSLGA 161_ EDTAS 166_ SQLGF 171_ GVLEL 176_ SQSQD 181_ VEENT 186_ VPYEV 191_ DKEQL 196_ QSVTT 201_ NSGYT 206_ RLSDV 211_ DANTA 216_ IKHEE 221_ QSNED 226_ IPIAE 231_ QSSKD 236_ IPVTA 241_ QPSKD 246_ VHVVK 251_ EQNPP 256_ PARSE 261_ DMPFS 266_ PKASV 271_ AAMEA 276_ KEQLS 281_ AQELM 286_ ESGLQ 291_ IQKSP 296_ EPEVL 301_ STQED 306_ LFDQS 311_ NKTVS 316_ SDGCS 321_ TPSRE 326_ EGGCS 331_ LASTP 336_ ATTLH 341_ LLQLS 346_ GQRSL 351_ VQDSL 356_ STNSS 361_ DLVAP 366_ SPDAF 371_ RSTPF 376_ IVPSS 381_ PTEQE 386_ GRQDK 391_ PMDTS 396_ VLSEE 401_ GGEPF 406_ QKKLQ 411_ SGEPV 416_ ELENP 421_ PLLPE 426_ STVSP 431_ QASTP 436_ ISQST 441_ PVFPP 446_ GSLPI 451_ PSQPQ 456_ FSHDI 461_ FIPSP 466_ SLEEQ 471_ SNDGK 476_ KDGDM 481_ HSSSL 486_ TVECS 491_ KTSEI 496_ EPKNS 501_ PEDLG 506_ LSLTG 511_ DSCKL 516_ MLSTS 521_ EYSQS 526_ PKMES 531_ LSSHR 536_ IDEDG 541_ ENTQI 546_ EDTEP 551_ MSPVL 556_ NSKFV 561_ PAEND 566_ SILMN 571_ PAQDG 576_ EVQLS 581_ QNDDK 586_ TKGDD 591_ TDTRD 596_ DISIL 601_ ATGCK 606_ GREET 611_ VAEDV 616_ CIDLT 621_ CDSGS 626_ QAVPS 631_ PATRS 636_ EALSS 641_ VLDQE 646_ EAMEI 651_ KEHHP 656_ EEGSS 661_ GSEVE 666_ EIPET 671_ PCESQ 676_ GEELK 681_ EENME 686_ SVPLH 691_ LSLTE 696_ TQSQG 701_ LCLQK 706_ EMPKK 711_ ECSEA 716_ MEVET 721_ SVISI 726_ DSPQK 731_ LAILD 736_ QELEH 741_ KEQEA 746_ WEEAT 751_ SEDSS 756_ VVIVD 761_ VKEPS 766_ PRVDV 771_ SCEPL 776_ EGVEK 781_ CSDSQ 786_ SWEDI 791_ APEIE 796_ PCAEN 801_ RLDTK 806_ EEKSV 811_ EYEGD 816_ LKSGT 821_ AETEP 826_ VEQDS 831_ SQPSL 836_ PLVRA 841_ DDPLR 846_ LDQEL 851_ QQPQT 856_ QEKTS 861_ NSLTE 866_ DSKMA 871_ NAKQL 876_ SSDAE 881_ AQKLG 886_ KPSAH 891_ ASQSF 896_ CESSS 901_ ETPFH 906_ FTLPK 911_ EGDII 916_ PPLTG 921_ ATPPL 926_ IGHLK 931_ LEPKR 936_ HSTPI 941_ GISNY 946_ PESTI 951_ ATSDV 956_ MSESM 961_ VETHD 966_ PILGS 971_ GKGDS 976_ GAAPD 981_ VDDKL 986_ CLRMK 991_ LVSPE 996_ TEASE 1001_ ESLQF 1006_ NLEKP 1011_ ATGER 1016_ KNGST 1021_ AVAES 1026_ VASPQ 1031_ KTMSV 1036_ LSCIC 1041_ EARQE 1046_ NEARS 1051_ EDPPT 1056_ TPIRG 1061_ NLLHF 1066_ PSSQG 1071_ EEEKE 1076_ KLEGD 1081_ HTIRQ 1086_ SQQPM 1091_ KPISP 1096_ VKDPV 1101_ SPASQ 1106_ KMVIQ 1111_ GPSSP 1116_ QGEAM 1121_ VTDVL 1126_ EDQKE 1131_ GRSTN 1136_ KENPS 1141_ KALIE 1146_ RPSQN 1151_ NIGIQ 1156_ TMECS 1161_ LRVPE 1166_ TVSAA 1171_ TQTIK 1176_ NVCEQ 1181_ GTSTV 1186_ DQNFG 1191_ KQDAT 1196_ VQTER 1201_ GSGEK 1206_ PVSAP 1211_ GDDTE 1216_ SLHSQ 1221_ GEEEF 1226_ DMPQP 1231_ PHGHV 1236_ LHRHM 1241_ RTIRE 1246_ VRTLV 1251_ TRVIT 1256_ DVYYV 1261_ DGTEV 1266_ ERKVT 1271_ EETEE 1276_ PIVEC 1281_ QECET 1286_ EVSPS 1291_ QTGGS 1296_ SGDLG 1301_ DISSF 1306_ SSKAS 1311_ SLHRT 1316_ SSGTS 1321_ LSAMH 1326_ SSGSS 1331_ GKGAG 1336_ PLRGK 1341_ TSGTE 1346_ PADFA 1351_ LPSSR 1356_ GGPGK 1361_ LSPRK 1366_ GVSQT 1371_ GTPVC 1376_ EEDGD 1381_ AGLGI 1386_ RQGGK 1391_ APVTP 1396_ RGRGR 1401_ RGRPP 1406_ SRTTG 1411_ TRETA 1416_ VPGPL 1421_ GIEDI 1426_ SPNLS 1431_ PDDKS 1436_ FSRVV 1441_ PRVPD 1446_ STRRT 1451_ DVGAG 1456_ ALRRS 1461_ DSPEI 1466_ PFQAA 1471_ AGPSD 1476_ GLDAS 1481_ SPGNS 1486_ FVGLR 1491_ VVAKW 1496_ SSNGY 1501_ FYSGK 1506_ ITRDV 1511_ GAGKY 1516_ KLLFD 1521_ DGYEC 1526_ DVLGK 1531_ DILLC 1536_ DPIPL 1541_ DTEVT 1546_ ALSED 1551_ EYFSA 1556_ GVVKG 1561_ HRKES 1566_ GELYY 1571_ SIEKE 1576_ GQRKW 1581_ YKRMA 1586_ VILSL 1591_ EQGNR 1596_ LREQY 1601_ GLGPY 1606_ EAVTP 1611_ LTKAA 1616_ DISLD 1621_ NLVEG 1626_ KRKRR 1631_ SNVSS 1636_ PATPT 1641_ ASSSS 1646_ STTPT 1651_ RKITE 1656_ SPRAS 1661_ MGVLS 1666_ GKRKL 1671_ ITSEE 1676_ ERSPA 1681_ KRGRK 1686_ SATVK 1691_ PGAVG 1696_ AGEFV 1701_ SPCES 1706_ GDNTG 1711_ EPSAL 1716_ EEQRG 1721_ PLPLN 1726_ KTLFL 1731_ GYAFL 1736_ LTMAT 1741_ TSDKL 1746_ ASRSK 1751_ LPDGP 1756_ TGSSE 1761_ EEEEF 1766_ LEIPP 1771_ FNKQY 1776_ TESQL 1781_ RAGAG 1786_ YILED 1791_ FNEAQ 1796_ CNTAY 1801_ QCLLI 1806_ ADQHC 1811_ RTRKY 1816_ FLCLA 1821_ SGIPC 1826_ VSHVW 1831_ VHDSC 1836_ HANQL 1841_ QNYRN 1846_ YLLPA 1851_ GYSLE 1856_ EQRIL 1861_ DWQPR 1866_ ENPFQ 1871_ NLKVL 1876_ LVSDQ 1881_ QQNFL 1886_ ELWSE 1891_ ILMTG 1896_ GAASV 1901_ KQHHS 1906_ SAHNK 1911_ DIALG 1916_ VFDVV 1921_ VTDPS 1926_ CPASV 1931_ LKCAE 1936_ ALQLP 1941_ VVSQE 1946_ WVIQC 1951_ LIVGE 1956_ RIGFK 1961_ QHPKY 1966_KHDYV
1: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112)