Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173)
1_MATSA 6_ PLRSL 11_ EEEVT 16_ CSICL 21_ DYLRD 26_ PVTID 31_ CGHVF 36_ CRSCT 41_ TDVRP 46_ ISGSR 51_ PVCPL 56_ CKKPF 61_ KKENI 66_ RPVWQ 71_ LASLV 76_ ENIER 81_ LKVDK 86_ GRQPG 91_ EVTRE 96_ QQDAK 101_ LCERH 106_ REKLH 111_ YYCED 116_ DGKLL 121_ CVMCR 126_ ESREH 131_ RPHTA 136_ VLMEK 141_ AAQPH 146_ REKIL 151_ NHLST 156_ LRRDR 161_ DKIQG 166_ FQAKG 171_ EADIL 176_ AALKK 181_ LQDQR 186_ QYIVA 191_ EFEQG 196_ HQFLR 201_ EREEH 206_ LLEQL 211_ AKLEQ 216_ ELTEG 221_ REKFK 226_ SRGVG 231_ ELARL 236_ ALVIS 241_ ELEGK 246_ AQQPA 251_ AELMQ 256_ DTRDF 261_ LNRYP 266_ RKKFW 271_ VGKPI 276_ ARVVK 281_ KKTGE 286_ FSDKL 291_ LSLQR 296_ GLREF 301_ QGKLL 306_ RDLEY 311_ KTVSV 316_ TLDPQ 321_ SASGY 326_ LQLSE 331_ DWKCV 336_ TYTSL 341_ YKSAY 346_ LHPQQ 351_ FDCEP 356_ GVLGS 361_ KGFTW 366_ GKVYW 371_ EVEVE 376_ REGWS 381_ EDEEE 386_ GDEEE 391_ EGEEE 396_ EEEEE 401_ AGYGD 406_ GYDDW 411_ ETDED 416_ EESLG 421_ DEEEE 426_ EEEEE 431_ EEVLE 436_ SCMVG 441_ VARDS 446_ VKRKG 451_ DLSLR 456_ PEDGV 461_ WALRL 466_ SSSGI 471_ WANTS 476_ PEAEL 481_ FPALR 486_ PRRVG 491_ IALDY 496_ EGGTV 501_ TFTNA 506_ ESQEL 511_ IYTFT 516_ ATFTR 521_ RLVPF 526_ LWLKW 531_PGTRL
1: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA (PubMed:29610152, PubMed:36232914). Promotes nuclear IRF3 ubiquitination and proteasomal degradation (PubMed:25763818). Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation (PubMed:34732716). Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein (PubMed:23452852). Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (PubMed:29203640). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). Inhibits directly hepatitis B virus replication by mediating HBX ubiquitination and subsequent degradation (PubMed:35872575)
2: (Microbial infection) Promotes herpes simplex virus type 2/HHV-2 infection in vaginal epithelial cells by decreasing the nuclear localization of IRF3, the primary mediator of type I interferon activation