Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)]
1_MANND 6_ AVLKR 11_ LEQKG 16_ AEADQ 21_ IIEYL 26_ KQQVS 31_ LLKEK 36_ AILQA 41_ TLREE 46_ KKLRV 51_ ENAKL 56_ KKEIE 61_ ELKQE 66_ LIQAE 71_ IQNGV 76_ KQIPF 81_ PSGTP 86_ LHANS 91_ MVSEN 96_ VIQST 101_ AVTTV 106_ SSGTK 111_ EQIKG 116_ GTGDE 121_ KKAKE 126_ KIEKK 131_ GEKKE 136_ KKQQS 141_ IAGSA 146_ DSKPI 151_ DVSRL 156_ DLRIG 161_ CIITA 166_ RKHPD 171_ ADSLY 176_ VEEVD 181_ VGEIA 186_ PRTVV 191_ SGLVN 196_ HVPLE 201_ QMQNR 206_ MVILL 211_ CNLKP 216_ AKMRG 221_ VLSQA 226_ MVMCA 231_ SSPEK 236_ IEILA 241_ PPNGS 246_ VPGDR 251_ ITFDA 256_ FPGEP 261_ DKELN 266_ PKKKI 271_ WEQIQ 276_ PDLHT 281_ NDECV 286_ ATYKG 291_ VPFEV 296_ KGKGV 301_ CRAQT 306_MSNSG
1: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550)