Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)
1_MRGDR 6_ GRGRG 11_ GRFGS 16_ RGGPG 21_ GGFRP 26_ FVPHI 31_ PFDFY 36_ LCEMA 41_ FPRVK 46_ PAPDE 51_ TSFSE 56_ ALLKR 61_ NQDLA 66_ PNSAE 71_ QASIL 76_ SLVTK 81_ INNVI 86_ DNLIV 91_ APGTF 96_ EVQIE 101_ EVRQV 106_ GSYKK 111_ GTMTT 116_ GHNVA 121_ DLVVI 126_ LKILP 131_ TLEAV 136_ AALGN 141_ KVVES 146_ LRAQD 151_ PSEVL 156_ TMLTN 161_ ETGFE 166_ ISSSD 171_ ATVKI 176_ LITTV 181_ PPNLR 186_ KLDPE 191_ LHLDI 196_ KVLQS 201_ ALAAI 206_ RHARW 211_ FEENA 216_ SQSTV 221_ KVLIR 226_ LLKDL 231_ RIRFP 236_ GFEPL 241_ TPWIL 246_ DLLGH 251_ YAVMN 256_ NPTRQ 261_ PLALN 266_ VAYRR 271_ CLQIL 276_ AAGLF 281_ LPGSV 286_ GITDP 291_ CESGN 296_ FRVHT 301_ VMTLE 306_ QQDMV 311_ CYTAQ 316_ TLVRI 321_ LSHGG 326_ FRKIL 331_ GQEGD 336_ ASYLA 341_ SEIST 346_ WDGVI 351_ VTPSE 356_ KAYEK 361_ PPEKK 366_ EGEEE 371_ EENTE 376_ EPPQG 381_EEEES
1: Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71
2: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3