Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)
1_MRPMR 6_ IFVND 11_ DRHVM 16_ AKHSS 21_ VYPTQ 26_ EELEA 31_ VQNMV 36_ SHTER 41_ ALKAV 46_ SDWID 51_ EQEKG 56_ SSEQA 61_ ESDNM 66_ DVPPE 71_ DDSKE 76_ GAGEQ 81_ KTEHM 86_ TRTLR 91_ GVMRV 96_ GLVAK 101_ GLLLK 106_ GDLDL 111_ ELVLL 116_ CKEKP 121_ TTALL 126_ DKVAD 131_ NLAIQ 136_ LAAVT 141_ EDKYE 146_ ILQSV 151_ DDAAI 156_ VIKNT 161_ KEPPL 166_ SLTIH 171_ LTSPV 176_ VREEM 181_ EKVLA 186_ GETLS 191_ VNDPP 196_ DVLDR 201_ QKCLA 206_ ALASL 211_ RHAKW 216_ FQARA 221_ NGLKS 226_ CVIVI 231_ RVLRD 236_ LCTRV 241_ PTWGP 246_ LRGWP 251_ LELLC 256_ EKSIG 261_ TANRP 266_ MGAGE 271_ ALRRV 276_ LECLA 281_ SGIVM 286_ PDGSG 291_ IYDPC 296_ EKEAT 301_ DAIGH 306_ LDRQQ 311_ REDIT 316_ QSAQH 321_ ALRLA 326_ AFGQL 331_ HKVLG 336_ MDPLP 341_ SKMPK 346_ KPKNE 351_ NPVDY 356_ TVQIP 361_ PSTTY 366_ AITPM 371_ KRPME 376_ EDGEE 381_ KSPSK 386_ KKKKI 391_ QKKEE 396_ KAEPP 401_ QAMNA 406_ LMRLN 411_ QLKPG 416_ LQYKL 421_ VSQTG 426_ PVHAP 431_ IFTMS 436_ VEVDG 441_ NSFEA 446_ SGPSK 451_ KTAKL 456_ HVAVK 461_ VLQDM 466_ GLPTG 471_ AEGRD 476_ SSKGE 481_ DSAEE 486_ TEAKP 491_ AVVAP 496_ APVVE 501_ AVSTP 506_ SAAFP 511_ SDATA 516_ EQGPI 521_ LTKHG 526_ KNPVM 531_ ELNEK 536_ RRGLK 541_ YELIS 546_ ETGGS 551_ HDKRF 556_ VMEVE 561_ VDGQK 566_ FQGAG 571_ SNKKV 576_ AKAYA 581_ ALAAL 586_ EKLFP 591_ DTPLA 596_ LDANK 601_ KKRAP 606_ VPVRG 611_ GPKFA 616_ AKPHN 621_ PGFGM 626_ GGPMH 631_ NEVPP 636_ PPNLR 641_ GRGRG 646_ GSIRG 651_ RGRGR 656_ GFGGA 661_ NHGGY 666_ MNAGA 671_ GYGSY 676_ GYGGN 681_ SATAG 686_ YSQFY 691_ SNGGH 696_ SGNAS 701_ GGGGG 706_ GGGGS 711_ SGYGS 716_ YYQGD 721_ NYNSP 726_ VPPKH 731_ AGKKQ 736_ PHGGQ 741_ QKPSY 746_ GSGYQ 751_ SHQGQ 756_ QQSYN 761_ QSPYS 766_ NYGPP 771_ QGKQK 776_ GYNHG 781_ QGSYS 786_ YSNSY 791_ NSPGG 796_ GGGSD 801_ YNYES 806_ KFNYS 811_ GSGGR 816_ SGGNS 821_ YGSGG 826_ ASYNP 831_ GSHGG 836_ YGGGS 841_ GGGSS 846_ YQGKQ 851_ GGYSQ 856_ SNYNS 861_ PGSGQ 866_ NYSGP 871_ PSSYQ 876_ SSQGG 881_ YGRNA 886_DHSMN
1: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552)
2: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3