Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)
1_MNDPN 6_ SCVDN 11_ ATVCS 16_ GASCV 21_ VPESN 26_ FNNIL 31_ SVVLS 36_ TVLTI 41_ LLALV 46_ MFSMG 51_ CNVEI 56_ KKFLG 61_ HIKRP 66_ WGICV 71_ GFLCQ 76_ FGIMP 81_ LTGFI 86_ LSVAF 91_ DILPL 96_ QAVVV 101_ LIIGC 106_ CPGGT 111_ ASNIL 116_ AYWVD 121_ GDMDL 126_ SVSMT 131_ TCSTL 136_ LALGM 141_ MPLCL 146_ LIYTK 151_ MWVDS 156_ GSIVI 161_ PYDNI 166_ GTSLV 171_ SLVVP 176_ VSIGM 181_ FVNHK 186_ WPQKA 191_ KIILK 196_ IGSIA 201_ GAILI 206_ VLIAV 211_ VGGIL 216_ YQSAW 221_ IIAPK 226_ LWIIG 231_ TIFPV 236_ AGYSL 241_ GFLLA 246_ RIAGL 251_ PWYRC 256_ RTVAF 261_ ETGMQ 266_ NTQLC 271_ STIVQ 276_ LSFTP 281_ EELNV 286_ VFTFP 291_ LIYSI 296_ FQLAF 301_ AAIFL 306_ GFYVA 311_ YKKCH 316_ GKNKA 321_ EIPES 326_ KENGT 331_ EPESS 336_ FYKAN 341_GGFQP
1: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321)