Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]
1_MESTP 6_ FSGVA 11_ NQIHT 16_ LCERP 21_ TYGEV 26_ KDGAL 31_ DVKRQ 36_ HKCPG 41_ PTSGP 46_ SPGTN 51_ LSGCI 56_ RMNDD 61_ PSMEE 66_ NGVER 71_ VCPES 76_ LLQSR 81_ EYSSL 86_ PLPRH 91_ TSSTD 96_ GTITS 101_ SDPGL 106_ EILNM 111_ ASCDL 116_ DRNSL 121_ CKKEE 126_ DTRSA 131_ SPTIE 136_ AQGTS 141_ PAHDN 146_ IAFQD 151_ STSKD 156_ KTILN 161_ LEAKE 166_ EPETI 171_ EEHKK 176_ EHASG 181_ DSVVS 186_ PLPVT 191_ TVKSV 196_ NLRQS 201_ ENTSA 206_ NEKEV 211_ EAEFL 216_ RLSLG 221_ FKCDW 226_ FTLEK 231_ RVKLE 236_ ERSRD 241_ LAEEN 246_ LKKEI 251_ TNCLK 256_ LLESL 261_ TPLCE 266_ DDNQA 271_ QEIIK 276_ KLEKS 281_ IKFLS 286_ QCAAR 291_ VASRA 296_ EMLGA 301_ INQES 306_ RVSKA 311_ VEVMI 316_ QHVEN 321_ LKRMY 326_ AKEHA 331_ ELEEL 336_ KQVLL 341_ QNERS 346_ FNPLE 351_ DDDDC 356_ QIKKR 361_ SASLN 366_ SKPSS 371_ LRRVT 376_ IASLP 381_ RNIGN 386_ AGMVA 391_ GMENN 396_ DRFSR 401_ RSSSW 406_ RILGS 411_ KQSEH 416_ RPSLP 421_ RFIST 426_ YSWAD 431_ AEEEK 436_ CELKT 441_ KDDSE 446_ PSGEE 451_ TVERT 456_ RKPSL 461_ SEKKN 466_ NPSKW 471_ DVSSV 476_ YDTIA 481_ SWATN 486_ LKSSI 491_ RKANK 496_ ALWLS 501_ IAFIV 506_ LFAAL 511_ MSFLT 516_ GQLFQ 521_ KSVDA 526_ APTQQ 531_ EDSWT 536_ SLEHI 541_ LWPFT 546_RLRHN
1: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)