Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
1_MKPAA 6_ REARL 11_ PPRSP 16_ GLRWA 21_ LPLLL 26_ LLLRL 31_ GQILC 36_ AGGTP 41_ SPIPD 46_ PSVAT 51_ VATGE 56_ NGITQ 61_ ISSTA 66_ ESFHK 71_ QNGTG 76_ TPQVE 81_ TNTSE 86_ DGESS 91_ GANDS 96_ LRTPE 101_ QGSNG 106_ TDGAS 111_ QKTPS 116_ STGPS 121_ PVFDI 126_ KAVSI 131_ SPTNV 136_ ILTWK 141_ SNDTA 146_ ASEYK 151_ YVVKH 156_ KMENE 161_ KTITV 166_ VHQPW 171_ CNITG 176_ LRPAT 181_ SYVFS 186_ ITPGI 191_ GNETW 196_ GDPRV 201_ IKVIT 206_ EPIPV 211_ SDLRV 216_ ALTGV 221_ RKAAL 226_ SWSNG 231_ NGTAS 236_ CRVLL 241_ ESIGS 246_ HEELT 251_ QDSRL 256_ QVNIS 261_ GLKPG 266_ VQYNI 271_ NPYLL 276_ QSNKT 281_ KGDPL 286_ GTEGG 291_ LDASN 296_ TERSR 301_ AGSPT 306_ APVHD 311_ ESLVG 316_ PVDPS 321_ SGQQS 326_ RDTEV 331_ LLVGL 336_ EPGTR 341_ YNATV 346_ YSQAA 351_ NGTEG 356_ QPQAI 361_ EFRTN 366_ AIQVF 371_ DVTAV 376_ NISAT 381_ SLTLI 386_ WKVSD 391_ NESSS 396_ NYTYK 401_ IHVAG 406_ ETDSS 411_ NLNVS 416_ EPRAV 421_ IPGLR 426_ SSTFY 431_ NITVC 436_ PVLGD 441_ IEGTP 446_ GFLQV 451_ HTPPV 456_ PVSDF 461_ RVTVV 466_ STTEI 471_ GLAWS 476_ SHDAE 481_ SFQMH 486_ ITQEG 491_ AGNSR 496_ VEITT 501_ NQSII 506_ IGGLF 511_ PGTKY 516_ CFEIV 521_ PKGPN 526_ GTEGA 531_ SRTVC 536_ NRTVP 541_ SAVFD 546_ IHVVY 551_ VTTTE 556_ MWLDW 561_ KSPDG 566_ ASEYV 571_ YHLVI 576_ ESKHG 581_ SNHTS 586_ TYDKA 591_ ITLQG 596_ LIPGT 601_ LYNIT 606_ ISPEV 611_ DHVWG 616_ DPNST 621_ AQYTR 626_ PSNVS 631_ NIDVS 636_ TNTTA 641_ ATLSW 646_ QNFDD 651_ ASPTY 656_ SYCLL 661_ IEKAG 666_ NSSNA 671_ TQVVT 676_ DIGIT 681_ DATVT 686_ ELIPG 691_ SSYTV 696_ EIFAQ 701_ VGDGI 706_ KSLEP 711_ GRKSF 716_ CTDPA 721_ SMASF 726_ DCEVV 731_ PKEPA 736_ LVLKW 741_ TCPPG 746_ ANAGF 751_ ELEVS 756_ SGAWN 761_ NATHL 766_ ESCSS 771_ ENGTE 776_ YRTEV 781_ TYLNF 786_ STSYN 791_ ISITT 796_ VSCGK 801_ MAAPT 806_ RNTCT 811_ TGITD 816_ PPPPD 821_ GSPNI 826_ TSVSH 831_ NSVKV 836_ KFSGF 841_ EASHG 846_ PIKAY 851_ AVILT 856_ TGEAG 861_ HPSAD 866_ VLKYT 871_ YEDFK 876_ KGASD 881_ TYVTY 886_ LIRTE 891_ EKGRS 896_ QSLSE 901_ VLKYE 906_ IDVGN 911_ ESTTL 916_ GYYNG 921_ KLEPL 926_ GSYRA 931_ CVAGF 936_ TNITF 941_ HPQNK 946_ GLIDG 951_ AESYV 956_ SFSRY 961_ SDAVS 966_ LPQDP 971_ GVICG 976_ AVFGC 981_ IFGAL 986_ VIVTV 991_ GGFIF 996_ WRKKR 1001_ KDAKN 1006_ NEVSF 1011_ SQIKP 1016_ KKSKL 1021_ IRVEN 1026_ FEAYF 1031_ KKQQA 1036_ DSNCG 1041_ FAEEY 1046_ EDLKL 1051_ VGISQ 1056_ PKYAA 1061_ ELAEN 1066_ RGKNR 1071_ YNNVL 1076_ PYDIS 1081_ RVKLS 1086_ VQTHS 1091_ TDDYI 1096_ NANYM 1101_ PGYHS 1106_ KKDFI 1111_ ATQGP 1116_ LPNTL 1121_ KDFWR 1126_ MVWEK 1131_ NVYAI 1136_ IMLTK 1141_ CVEQG 1146_ RTKCE 1151_ EYWPS 1156_ KQAQD 1161_ YGDIT 1166_ VAMTS 1171_ EIVLP 1176_ EWTIR 1181_ DFTVK 1186_ NIQTS 1191_ ESHPL 1196_ RQFHF 1201_ TSWPD 1206_ HGVPD 1211_ TTDLL 1216_ INFRY 1221_ LVRDY 1226_ MKQSP 1231_ PESPI 1236_ LVHCS 1241_ AGVGR 1246_ TGTFI 1251_ AIDRL 1256_ IYQIE 1261_ NENTV 1266_ DVYGI 1271_ VYDLR 1276_ MHRPL 1281_ MVQTE 1286_ DQYVF 1291_ LNQCV 1296_ LDIVR 1301_ SQKDS 1306_ KVDLI 1311_ YQNTT 1316_ AMTIY 1321_ ENLAP 1326_ VTTFG 1331_KTNGY
1: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111)
2: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032)