Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)
1_MDQQA 6_ IYAEL 11_ NLPTD 16_ SGPES 21_ SSPSS 26_ LPRDV 31_ CQGSP 36_ WHQFA 41_ LKLSC 46_ AGIIL 51_ LVLVV 56_ TGLSV 61_ SVTSL 66_ IQKSS 71_ IEKCS 76_ VDIQQ 81_ SRNKT 86_ TERPG 91_ LLNCP 96_ IYWQQ 101_ LREKC 106_ LLFSH 111_ TVNPW 116_ NNSLA 121_ DCSTK 126_ ESSLL 131_ LIRDK 136_ DELIH 141_ TQNLI 146_ RDKAI 151_ LFWIG 156_ LNFSL 161_ SEKNW 166_ KWING 171_ SFLNS 176_ NDLEI 181_ RGDAK 186_ ENSCI 191_ SISQT 196_ SVYSE 201_ YCSTE 206_ IRWIC 211_ QKELT 216_PVRNK
1: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells