Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
1_MAREL 6_ RALLL 11_ WGRRL 16_ RPLLR 21_ APALA 26_ AVPGG 31_ KPILC 36_ PRRTT 41_ AQLGP 46_ RRNPA 51_ WSLQA 56_ GRLFS 61_ TQTAE 66_ DKEEP 71_ LHSII 76_ SSTES 81_ VQGST 86_ SKHEF 91_ QAETK 96_ KLLDI 101_ VARSL 106_ YSEKE 111_ VFIRE 116_ LISNA 121_ SDALE 126_ KLRHK 131_ LVSDG 136_ QALPE 141_ MEIHL 146_ QTNAE 151_ KGTIT 156_ IQDTG 161_ IGMTQ 166_ EELVS 171_ NLGTI 176_ ARSGS 181_ KAFLD 186_ ALQNQ 191_ AEASS 196_ KIIGQ 201_ FGVGF 206_ YSAFM 211_ VADRV 216_ EVYSR 221_ SAAPG 226_ SLGYQ 231_ WLSDG 236_ SGVFE 241_ IAEAS 246_ GVRTG 251_ TKIII 256_ HLKSD 261_ CKEFS 266_ SEARV 271_ RDVVT 276_ KYSNF 281_ VSFPL 286_ YLNGR 291_ RMNTL 296_ QAIWM 301_ MDPKD 306_ VREWQ 311_ HEEFY 316_ RYVAQ 321_ AHDKP 326_ RYTLH 331_ YKTDA 336_ PLNIR 341_ SIFYV 346_ PDMKP 351_ SMFDV 356_ SRELG 361_ SSVAL 366_ YSRKV 371_ LIQTK 376_ ATDIL 381_ PKWLR 386_ FIRGV 391_ VDSED 396_ IPLNL 401_ SRELL 406_ QESAL 411_ IRKLR 416_ DVLQQ 421_ RLIKF 426_ FIDQS 431_ KKDAE 436_ KYAKF 441_ FEDYG 446_ LFMRE 451_ GIVTA 456_ TEQEV 461_ KEDIA 466_ KLLRY 471_ ESSAL 476_ PSGQL 481_ TSLSE 486_ YASRM 491_ RAGTR 496_ NIYYL 501_ CAPNR 506_ HLAEH 511_ SPYYE 516_ AMKKK 521_ DTEVL 526_ FCFEQ 531_ FDELT 536_ LLHLR 541_ EFDKK 546_ KLISV 551_ ETDIV 556_ VDHYK 561_ EEKFE 566_ DRSPA 571_ AECLS 576_ EKETE 581_ ELMAW 586_ MRNVL 591_ GSRVT 596_ NVKVT 601_ LRLDT 606_ HPAMV 611_ TVLEM 616_ GAARH 621_ FLRMQ 626_ QLAKT 631_ QEERA 636_ QLLQP 641_ TLEIN 646_ PRHAL 651_ IKKLN 656_ QLRAS 661_ EPGLA 666_ QLLVD 671_ QIYEN 676_ AMIAA 681_ GLVDD 686_ PRAMV 691_ GRLNE 696_LLVKA
1: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA