TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
1_MAAAS 6_ VTPPG 11_ SLELL 16_ QPGFS 21_ KTLLG 26_ TKLEA 31_ KYLCS 36_ ACRNV 41_ LRRPF 46_ QAQCG 51_ HRYCS 56_ FCLAS 61_ ILSSG 66_ PQNCA 71_ ACVHE 76_ GIYEE 81_ GISIL 86_ ESSSA 91_ FPDNA 96_ ARREV 101_ ESLPA 106_ VCPSD 111_ GCTWK 116_ GTLKE 121_ YESCH 126_ EGRCP 131_ LMLTE 136_ CPACK 141_ GLVRL 146_ GEKER 151_ HLEHE 156_ CPERS 161_ LSCRH 166_ CRAPC 171_ CGADV 176_ KAHHE 181_ VCPKF 186_ PLTCD 191_ GCGKK 196_ KIPRE 201_ KFQDH 206_ VKTCG 211_ KCRVP 216_ CRFHA 221_ IGCLE 226_ TVEGE 231_ KQQEH 236_ EVQWL 241_ REHLA 246_ MLLSS 251_ VLEAK 256_ PLLGD 261_ QSHAG 266_ SELLQ 271_ RCESL 276_ EKKTA 281_ TFENI 286_ VCVLN 291_ REVER 296_ VAMTA 301_ EACSR 306_ QHRLD 311_ QDKIE 316_ ALSSK 321_ VQQLE 326_ RSIGL 331_ KDLAM 336_ ADLEQ 341_ KVLEM 346_ EASTY 351_ DGVFI 356_ WKISD 361_ FARKR 366_ QEAVA 371_ GRIPA 376_ IFSPA 381_ FYTSR 386_ YGYKM 391_ CLRIY 396_ LNGDG 401_ TGRGT 406_ HLSLF 411_ FVVMK 416_ GPNDA 421_ LLRWP 426_ FNQKV 431_ TLMLL 436_ DQNNR 441_ EHVID 446_ AFRPD 451_ VTSSS 456_ FQRPV 461_ NDMNI 466_ ASGCP 471_ LFCPV 476_ SKMEA 481_ KNSYV 486_ RDDAI 491_ FIKAI 496_VDLTG
1: E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:10346818, PubMed:11784851, PubMed:12917689, PubMed:15383523, PubMed:18981220, PubMed:19150425, PubMed:19810754, PubMed:19918265, PubMed:19937093, PubMed:20047764, PubMed:20064526, PubMed:20385093, PubMed:20577214, PubMed:22212761). Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1 (PubMed:23453969, PubMed:28489822). Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases (PubMed:15383523, PubMed:18981220). Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain (PubMed:11907583, PubMed:19506082). Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR (PubMed:15121867). In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE (PubMed:23453969). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex (PubMed:28489822). Required for normal antibody isotype switching from IgM to IgG (By similarity)