Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)
1_MQARY 6_ SVSSP 11_ NSLGV 16_ VPYLG 21_ GEQSY 26_ YRAAA 31_ AAAGG 36_ GYTAM 41_ PAPMS 46_ VYSHP 51_ AHAEQ 56_ YPGGM 61_ ARAYG 66_ PYTPQ 71_ PQPKD 76_ MVKPP 81_ YSYIA 86_ LITMA 91_ IQNAP 96_ DKKIT 101_ LNGIY 106_ QFIMD 111_ RFPFY 116_ RDNKQ 121_ GWQNS 126_ IRHNL 131_ SLNEC 136_ FVKVP 141_ RDDKK 146_ PGKGS 151_ YWTLD 156_ PDSYN 161_ MFENG 166_ SFLRR 171_ RRRFK 176_ KKDAV 181_ KDKEE 186_ KDRLH 191_ LKEPP 196_ PPGRQ 201_ PPPAP 206_ PEQAD 211_ GNAPG 216_ PQPPP 221_ VRIQD 226_ IKTEN 231_ GTCPS 236_ PPQPL 241_ SPAAA 246_ LGSGS 251_ AAAVP 256_ KIESP 261_ DSSSS 266_ SLSSG 271_ SSPPG 276_ SLPSA 281_ RPLSL 286_ DGADS 291_ APPPP 296_ APSAP 301_ PPHHS 306_ QGFSV 311_ DNIMT 316_ SLRGS 321_ PQSAA 326_ AELSS 331_ GLLAS 336_ AAASS 341_ RAGIA 346_ PPLAL 351_ GAYSP 356_ GQSSL 361_ YSSPC 366_ SQTSS 371_ AGSSG 376_ GGGGG 381_ AGAAG 386_ GAGGA 391_ GTYHC 396_ NLQAM 401_ SLYAA 406_ GERGG 411_ HLQGA 416_ PGGAG 421_ GSAVD 426_ DPLPD 431_ YSLPP 436_ VTSSS 441_ SSSLS 446_ HGGGG 451_ GGGGG 456_ GQEAG 461_ HHPAA 466_ HQGRL 471_ TSWYL 476_ NQAGG 481_ DLGHL 486_ ASAAA 491_ AAAAA 496_ GYPGQ 501_ QQNFH 506_ SVREM 511_ FESQR 516_ IGLNN 521_ SPVNG 526_ NSSCQ 531_ MAFPS 536_ SQSLY 541_ RTSGA 546_FVYDC
1: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963)