Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
1_MPVRK 6_ QDTQR 11_ ALHLL 16_ EEYRS 21_ KLSQT 26_ EDRQL 31_ RSSIE 36_ RVINI 41_ FQSNL 46_ FQALI 51_ DIQEF 56_ YEVTL 61_ LDNPK 66_ CIDRS 71_ KPSEP 76_ IQPVN 81_ TWEIS 86_ SLPSS 91_ TVTSE 96_ TLPSS 101_ LSPSV 106_ EKYRY 111_ QDEDT 116_ PPQEH 121_ ISPQI 126_ TNEVI 131_ GPELV 136_ HVSEK 141_ NLSEI 146_ ENVHG 151_ FVSHS 156_ HISPI 161_ KPTEA 166_ VLPSP 171_ PTVPV 176_ IPVLP 181_ VPAEN 186_ TVILP 191_ TIPQA 196_ NPPPV 201_ LVNTD 206_ SLETP 211_ TYVNG 216_ TDADY 221_ EYEEI 226_ TLERG 231_ NSGLG 236_ FSIAG 241_ GTDNP 246_ HIGDD 251_ SSIFI 256_ TKIIT 261_ GGAAA 266_ QDGRL 271_ RVNDC 276_ ILRVN 281_ EVDVR 286_ DVTHS 291_ KAVEA 296_ LKEAG 301_ SIVRL 306_ YVKRR 311_ KPVSE 316_ KIMEI 321_ KLIKG 326_ PKGLG 331_ FSIAG 336_ GVGNQ 341_ HIPGD 346_ NSIYV 351_ TKIIE 356_ GGAAH 361_ KDGKL 366_ QIGDK 371_ LLAVN 376_ NVCLE 381_ EVTHE 386_ EAVTA 391_ LKNTS 396_ DFVYL 401_ KVAKP 406_ TSMYM 411_ NDGYA 416_ PPDIT 421_ NSSSQ 426_ PVDNH 431_ VSPSS 436_ FLGQT 441_ PASPA 446_ RYSPV 451_ SKAVL 456_ GDDEI 461_ TREPR 466_ KVVLH 471_ RGSTG 476_ LGFNI 481_ VGGED 486_ GEGIF 491_ ISFIL 496_ AGGPA 501_ DLSGE 506_ LRKGD 511_ RIISV 516_ NSVDL 521_ RAASH 526_ EQAAA 531_ ALKNA 536_ GQAVT 541_ IVAQY 546_ RPEEY 551_ SRFEA 556_ KIHDL 561_ REQMM 566_ NSSIS 571_ SGSGS 576_ LRTSQ 581_ KRSLY 586_ VRALF 591_ DYDKT 596_ KDSGL 601_ PSQGL 606_ NFKFG 611_ DILHV 616_ INASD 621_ DEWWQ 626_ ARQVT 631_ PDGES 636_ DEVGV 641_ IPSKR 646_ RVEKK 651_ ERARL 656_ KTVKF 661_ NSKTR 666_ DKGEI 671_ PDDMG 676_ SKGLK 681_ HVTSN 686_ ASDSE 691_ SSYRG 696_ QEEYV 701_ LSYEP 706_ VNQQE 711_ VNYTR 716_ PVIIL 721_ GPMKD 726_ RINDD 731_ LISEF 736_ PDKFG 741_ SCVPH 746_ TTRPK 751_ RDYEV 756_ DGRDY 761_ HFVTS 766_ REQME 771_ KDIQE 776_ HKFIE 781_ AGQYN 786_ NHLYG 791_ TSVQS 796_ VREVA 801_ EKGKH 806_ CILDV 811_ SGNAI 816_ KRLQI 821_ AQLYP 826_ ISIFI 831_ KPKSM 836_ ENIME 841_ MNKRL 846_ TEEQA 851_ RKTFE 856_ RAMKL 861_ EQEFT 866_ EHFTA 871_ IVQGD 876_ TLEDI 881_ YNQVK 886_ QIIEE 891_ QSGSY 896_IWVPA
1: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497)