Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)
1_MGSKG 6_ VYQYH 11_ WQSHN 16_ VKHSG 21_ VDDMV 26_ LLSKI 31_ TENSI 36_ VENLK 41_ KRYMD 46_ DYIFT 51_ YIGSV 56_ LISVN 61_ PFKQM 66_ PYFGE 71_ KEIEM 76_ YQGAA 81_ QYENP 86_ PHIYA 91_ LADNM 96_ YRNMI 101_ IDREN 106_ QCVII 111_ SGESG 116_ AGKTV 121_ AAKYI 126_ MSYIS 131_ RVSGG 136_ GTKVQ 141_ HVKDI 146_ ILQSN 151_ PLLEA 156_ FGNAK 161_ TVRNN 166_ NSSRF 171_ GKYFE 176_ IQFSP 181_ GGEPD 186_ GGKIS 191_ NFLLE 196_ KSRVV 201_ MRNPG 206_ ERSFH 211_ IFYQL 216_ IEGAS 221_ AEQKH 226_ SLGIT 231_ SMDYY 236_ YYLSL 241_ SGSYK 246_ VDDID 251_ DRREF 256_ QETLH 261_ AMNVI 266_ GIFAE 271_ EQTLV 276_ LQIVA 281_ GILHL 286_ GNISF 291_ KEVGN 296_ YAAVE 301_ SEEFL 306_ AFPAY 311_ LLGIN 316_ QDRLK 321_ EKLTS 326_ RQMDS 331_ KWGGK 336_ SESIH 341_ VTLNV 346_ EQACY 351_ TRDAL 356_ AKALH 361_ ARVFD 366_ FLVDS 371_ INKAM 376_ EKDHE 381_ EYNIG 386_ VLDIY 391_ GFEIF 396_ QKNGF 401_ EQFCI 406_ NFVNE 411_ KLQQI 416_ FIELT 421_ LKAEQ 426_ EEYVQ 431_ EGIRW 436_ TPIEY 441_ FNNKI 446_ VCDLI 451_ ENKVN 456_ PPGIM 461_ SILDD 466_ VCATM 471_ HAVGE 476_ GADQT 481_ LLQKL 486_ QMQIG 491_ SHEHF 496_ NSWNQ 501_ GFIIH 506_ HYAGK 511_ VSYDM 516_ DGFCE 521_ RNRDV 526_ LFMDL 531_ IELMQ 536_ SSELP 541_ FIKSL 546_ FPENL 551_ QADKK 556_ GRPTT 561_ AGSKI 566_ KKQAN 571_ DLVST 576_ LMKCT 581_ PHYIR 586_ CIKPN 591_ ETKKP 596_ RDWEE 601_ SRVKH 606_ QVEYL 611_ GLKEN 616_ IRVRR 621_ AGYAY 626_ RRIFQ 631_ KFLQR 636_ YAILT 641_ KATWP 646_ SWQGE 651_ EKQGV 656_ LHLLQ 661_ SVNMD 666_ SDQFQ 671_ LGRSK 676_ VFIKA 681_ PESLF 686_ LLEEM 691_ RERKY 696_ DGYAR 701_ VIQKS 706_ WRKFV 711_ ARKKY 716_ VQMRE 721_ EASDL 726_ LLNKK 731_ ERRRN 736_ SINRN 741_ FIGDY 746_ IGMEE 751_ HPELQ 756_ QFVGK 761_ REKID 766_ FADTV 771_ TKYDR 776_ RFKGV 781_ KRDLL 786_ LTPKC 791_ LYLIG 796_ REKVK 801_ QGPDK 806_ GLVKE 811_ VLKRK 816_ IEIER 821_ ILSVS 826_ LSTMQ 831_ DDIFI 836_ LHEQE 841_ YDSLL 846_ ESVFK 851_ TEFLS 856_ LLAKR 861_ YEEKT 866_ QKQLP 871_ LKFSN 876_ TLELK 881_ LKKEN 886_ WGPWS 891_ AGGSR 896_ QVQFH 901_ QGFGD 906_ LAVLK 911_ PSNKV 916_ LQVSI 921_ GPGLP 926_ KNSRP 931_ TRRNT 936_ TQNTG 941_ YSSGT 946_ QNANY 951_ PVRAA 956_ PPPPG 961_ YHQNG 966_ VIRNQ 971_ YVPYP 976_ HAPGS 981_ QRSNQ 986_ KSLYT 991_ SMARP 996_ PLPRQ 1001_ QSTSS 1006_ DRVSQ 1011_ TPESL 1016_ DFLKV 1021_ PDQGA 1026_ AGVRR 1031_ QTTSR 1036_ PPPAG 1041_ GRPKP 1046_ QPKPK 1051_ PQVPQ 1056_ CKALY 1061_ AYDAQ 1066_ DTDEL 1071_ SFNAN 1076_ DIIDI 1081_ IKEDP 1086_ SGWWT 1091_ GRLRG 1096_ KQGLF 1101_PNNYV
1: Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14