Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c)
1_MTTAN 6_ CGAHD 11_ ELDFK 16_ LVFGE 21_ DGAPA 26_ PPPPG 31_ SRPAD 36_ LEPDD 41_ CASIY 46_ IFNVD 51_ PPPST 56_ LTTPL 61_ CLPHH 66_ GLPSH 71_ SSVLS 76_ PSFQL 81_ QSHKN 86_ YEGTC 91_ EIPES 96_ KYSPL 101_ GGPKP 106_ FECPS 111_ IQITS 116_ ISPNC 121_ HQELD 126_ AHEDD 131_ LQIND 136_ PEREF 141_ LERPS 146_ RDHLY 151_ LPLEP 156_ SYRES 161_ SLSPS 166_ PASSI 171_ SSRSW 176_ FSDAS 181_ SCESL 186_ SHIYD 191_ DVDSE 196_ LNEAA 201_ ARFTL 206_ GSPLT 211_ SPGGS 216_ PGGCP 221_ GEETW 226_ HQQYG 231_ LGHSL 236_ SPRQS 241_ PCHSP 246_ RSSVT 251_ DENWL 256_ SPRPA 261_ SGPSS 266_ RPTSP 271_ CGKRR 276_ HSSAE 281_ VCYAG 286_ SLSPH 291_ HSPVP 296_ SPGHS 301_ PRGSV 306_ TEDTW 311_ LNASV 316_ HGGSG 321_ LGPAV 326_ FPFQY 331_ CVETD 336_ IPLKT 341_ RKTSE 346_ DQAAI 351_ LPGKL 356_ ELCSD 361_ DQGSL 366_ SPARE 371_ TSIDD 376_ GLGSQ 381_ YPLKK 386_ DSCGD 391_ QFLSV 396_ PSPFT 401_ WSKPK 406_ PGHTP 411_ IFRTS 416_ SLPPL 421_ DWPLP 426_ AHFGQ 431_ CELKI 436_ EVQPK 441_ THHRA 446_ HYETE 451_ GSRGA 456_ VKAST 461_ GGHPV 466_ VKLLG 471_ YNEKP 476_ INLQM 481_ FIGTA 486_ DDRYL 491_ RPHAF 496_ YQVHR 501_ ITGKT 506_ VATAS 511_ QEIII 516_ ASTKV 521_ LEIPL 526_ LPENN 531_ MSASI 536_ DCAGI 541_ LKLRN 546_ SDIEL 551_ RKGET 556_ DIGRK 561_ NTRVR 566_ LVFRV 571_ HIPQP 576_ SGKVL 581_ SLQIA 586_ SIPVE 591_ CSQRS 596_ AQELP 601_ HIEKY 606_ SINSC 611_ SVNGG 616_ HEMVV 621_ TGSNF 626_ LPESK 631_ IIFLE 636_ KGQDG 641_ RPQWE 646_ VEGKI 651_ IREKC 656_ QGAHI 661_ VLEVP 666_ PYHNP 671_ AVTAA 676_ VQVHF 681_ YLCNG 686_ KRKKS 691_ QSQRF 696_ TYTPV 701_ LMKQE 706_ HREEI 711_ DLSSV 716_ PSLPV 721_ PHPAQ 726_ TQRPS 731_ SDSGC 736_ SHDSV 741_ LSGQR 746_ SLICS 751_ IPQTY 756_ ASMVT 761_ SSHLP 766_ QLQCR 771_ DESVS 776_ KEQHM 781_ IPSPI 786_ VHQPF 791_ QVTPT 796_ PPVGS 801_ SYQPM 806_ QTNVV 811_ YNGPT 816_ CLPIN 821_ AASSQ 826_ EFDSV 831_ LFQQD 836_ ATLSG 841_ LVNLG 846_ CQPLS 851_ SIPFH 856_ SSNSG 861_ STGHL 866_ LAHTP 871_ HSVHT 876_ LPHLQ 881_ SMGYH 886_ CSNTG 891_ QRSLS 896_ SPVAD 901_ QITGQ 906_ PSSQL 911_ QPITY 916_ GPSHS 921_ GSATT 926_ ASPAA 931_ SHPLA 936_ SSPLS 941_ GPPSP 946_ QLQPM 951_ PYQSP 956_ SSGTA 961_ SSPSP 966_ ATRMH 971_ SGQHS 976_ TQAQS 981_ TGQGG 986_ LSAPS 991_ SLICH 996_ SLCDP 1001_ ASFPP 1006_ DGATV 1011_ SIKPE 1016_ PEDRE 1021_ PNFAT 1026_ IGLQD 1031_ ITLDD 1036_ VNEII 1041_ GRDMS 1046_ QISVS 1051_ QGAGV 1056_ SRQAP 1061_ LPSPE 1066_SLDLG
1: Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels