Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]
1_MAAAA 6_ NSGSS 11_ LPLFD 16_ CPTWA 21_ GKPPP 26_ GLHLD 31_ VVKGD 36_ KLIEK 41_ LIIDE 46_ KKYYL 51_ FGRNP 56_ DLCDF 61_ TIDHQ 66_ SCSRV 71_ HAALV 76_ YHKHL 81_ KRVFL 86_ IDLNS 91_ THGTF 96_ LGHIR 101_ LEPHK 106_ PQQIP 111_ IDSTV 116_ SFGAS 121_ TRAYT 126_ LREKP 131_ QTLPS 136_ AVKGD 141_ EKMGG 146_ EDDEL 151_ KGLLG 156_ LPEEE 161_ TELDN 166_ LTEFN 171_ TAHNK 176_ RISTL 181_ TIEEG 186_ NLDIQ 191_ RPKRK 196_ RKNSR 201_ VTFSE 206_ DDEII 211_ NPEDV 216_ DPSVG 221_ RFRNM 226_ VQTAV 231_ VPVKK 236_ KRVEG 241_ PGSLG 246_ LEESG 251_ SRRMQ 256_ NFAFS 261_ GGLYG 266_ GLPPT 271_ HSEAG 276_ SQPHG 281_ IHGTA 286_ LIGGL 291_ PMPYP 296_ NLAPD 301_ VDLTP 306_ VVPSA 311_ VNMNP 316_ APNPA 321_ VYNPE 326_ AVNEP 331_ KKKKY 336_ AKEAW 341_ PGKKP 346_TPSLL
1: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation
2: Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing