GATOR complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)
1_MRDNT 6_ SPISV 11_ ILVSS 16_ GSRGN 21_ KLLFR 26_ YPFQR 31_ SQEHP 36_ ASQTS 41_ KPRSR 46_ YAASN 51_ TGDHA 56_ DEQDG 61_ DSRFS 66_ DVILA 71_ TILAT 76_ KSEMC 81_ GQKFE 86_ LKIDN 91_ VRFVG 96_ HPTLL 101_ QHALG 106_ QISKT 111_ DPSPK 116_ REAPT 121_ MILFN 126_ VVFAL 131_ RANAD 136_ PSVIN 141_ CLHNL 146_ SRRIA 151_ TVLQH 156_ EERRC 161_ QYLTR 166_ EAKLI 171_ LALQD 176_ EVSAM 181_ ADGNE 186_ GPQSP 191_ FHHIL 196_ PKCKL 201_ ARDLK 206_ EAYDS 211_ LCTSG 216_ VVRLH 221_ INSWL 226_ EVSFC 231_ LPHKI 236_ HYAAS 241_ SLIPP 246_ EAIER 251_ SLKAI 256_ RPYHA 261_ LLLLS 266_ DEKSL 271_ LGELP 276_ IDCSP 281_ ALVRV 286_ IKTTS 291_ AVKNL 296_ QQLAQ 301_ DADLA 306_ LLQVF 311_ QLAAH 316_ LVYWG 321_ KAIII 326_ YPLCE 331_ NNVYM 336_ LSPNA 341_ SVCLY 346_ SPLAE 351_ QFSHQ 356_ FPSHD 361_ LPSVL 366_ AKFSL 371_ PVSLS 376_ EFRNP 381_ LAPAV 386_ QETQL 391_ IQMVV 396_ WMLQR 401_ RLLIQ 406_ LHTYV 411_ CLMAS 416_ PSEEE 421_ PRPRE 426_ DDVPF 431_ TARVG 436_ GRSLS 441_ TPNAL 446_ SFGSP 451_ TSSDD 456_ MTLTS 461_ PSMDN 466_ SSAEL 471_ LPSGD 476_ SPLNQ 481_ RMTEN 486_ LLASL 491_ SEHER 496_ AAILS 501_ VPAAQ 506_ NPEDL 511_ RMFAR 516_ LLHYF 521_ RGRHH 526_ LEEIM 531_ YNENT 536_ RRSQL 541_ LMLFD 546_ KFRSV 551_ LVVTT 556_ HEDPV 561_IAVFQ
1: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:29590090, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:29590090, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238)