BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
1_MSQNG 6_ APGMQ 11_ EESLQ 16_ GSWVE 21_ LHFSN 26_ NGNGG 31_ SVPAS 36_ VSIYN 41_ GDMEK 46_ ILLDA 51_ QHESG 56_ RSSSK 61_ SSHCD 66_ SPPRS 71_ QTPQD 76_ TNRAS 81_ ETDTH 86_ SIGEK 91_ NSSQS 96_ EEDDI 101_ ERRKE 106_ VESIL 111_ KKNSD 116_ WIWDW 121_ SSRPE 126_ NIPPK 131_ EFLFK 136_ HPKRT 141_ ATLSM 146_ RNTSV 151_ MKKGG 156_ IFSAE 161_ FLKVF 166_ LPSLL 171_ LSHLL 176_ AIGLG 181_ IYIGR 186_RLTTS
1: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway