Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
1_MKIIF 6_ PILSN 11_ PVFRR 16_ TVKLL 21_ LCLLW 26_ IGYSQ 31_ GTTHV 36_ LRFGG 41_ IFEYV 46_ ESGPM 51_ GAEEL 56_ AFRFA 61_ VNTIN 66_ RNRTL 71_ LPNTT 76_ LTYDT 81_ QKINL 86_ YDSFE 91_ ASKKA 96_ CDQLS 101_ LGVAA 106_ IFGPS 111_ HSSSA 116_ NAVQS 121_ ICNAL 126_ GVPHI 131_ QTRWK 136_ HQVSD 141_ NKDSF 146_ YVSLY 151_ PDFSS 156_ LSRAI 161_ LDLVQ 166_ FFKWK 171_ TVTVV 176_ YDDST 181_ GLIRL 186_ QELIK 191_ APSRY 196_ NLRLK 201_ IRQLP 206_ ADTKD 211_ AKPLL 216_ KEMKR 221_ GKEFH 226_ VIFDC 231_ SHEMA 236_ AGILK 241_ QALAM 246_ GMMTE 251_ YYHYI 256_ FTTLD 261_ LFALD 266_ VEPYR 271_ YSGVN 276_ MTGFR 281_ ILNTE 286_ NTQVS 291_ SIIEK 296_ WSMER 301_ LQAPP 306_ KPDSG 311_ LLDGF 316_ MTTDA 321_ ALMYD 326_ AVHVV 331_ SVAVQ 336_ QFPQM 341_ TVSSL 346_ QCNRH 351_ KPWRF 356_ GTRFM 361_ SLIKE 366_ AHWEG 371_ LTGRI 376_ TFNKT 381_ NGLRT 386_ DFDLD 391_ VISLK 396_ EEGLE 401_ KIGTW 406_ DPASG 411_ LNMTE 416_ SQKGK 421_ PANIT 426_ DSLSN 431_ RSLIV 436_ TTILE 441_ EPYVL 446_ FKKSD 451_ KPLYG 456_ NDRFE 461_ GYCID 466_ LLREL 471_ STILG 476_ FTYEI 481_ RLVED 486_ GKYGA 491_ QDDAN 496_ GQWNG 501_ MVREL 506_ IDHKA 511_ DLAVA 516_ PLAIT 521_ YVREK 526_ VIDFS 531_ KPFMT 536_ LGISI 541_ LYRKP 546_ NGTNP 551_ GVFSF 556_ LNPLS 561_ PDIWM 566_ YILLA 571_ YLGVS 576_ CVLFV 581_ IARFS 586_ PYEWY 591_ NPHPC 596_ NPDSD 601_ VVENN 606_ FTLLN 611_ SFWFG 616_ VGALM 621_ QQGSE 626_ LMPKA 631_ LSTRI 636_ VGGIW 641_ WFFTL 646_ IIISS 651_ YTANL 656_ AAFLT 661_ VERME 666_ SPIDS 671_ ADDLA 676_ KQTKI 681_ EYGAV 686_ EDGAT 691_ MTFFK 696_ KSKIS 701_ TYDKM 706_ WAFMS 711_ SRRQS 716_ VLVKS 721_ NEEGI 726_ QRVLT 731_ SDYAF 736_ LMEST 741_ TIEFV 746_ TQRNC 751_ NLTQI 756_ GGLID 761_ SKGYG 766_ VGTPM 771_ GSPYR 776_ DKITI 781_ AILQL 786_ QEEGK 791_ LHMMK 796_ EKWWR 801_ GNGCP 806_ EEESK 811_ EASAL 816_ GVQNI 821_ GGIFI 826_ VLAAG 831_ LVLSV 836_ FVAVG 841_ EFLYK 846_ SKKNA 851_ QLEKR 856_ SFCSA 861_ MVEEL 866_ RMSLK 871_ CQRRL 876_ KHKPQ 881_ APVIV 886_ KTEEV 891_ INMHT 896_ FNDRR 901_LPGKE
1: Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589). Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity)
2: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity)