Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)
1_MNFQQ 6_ RLQSL 11_ WTLAR 16_ PFCPP 21_ LLATA 26_ SQMQM 31_ VVLPC 36_ LGFTL 41_ LLWSQ 46_ VSGAQ 51_ GQEFH 56_ FGPCQ 61_ VKGVV 66_ PQKLW 71_ EAFWA 76_ VKDTM 81_ QAQDN 86_ ITSAR 91_ LLQQE 96_ VLQNV 101_ SDAES 106_ CYLVH 111_ TLLEF 116_ YLKTV 121_ FKNYH 126_ NRTVE 131_ VRTLK 136_ SFSTL 141_ ANNFV 146_ LIVSQ 151_ LQPSQ 156_ ENEMF 161_ SIRDS 166_ AHRRF 171_ LLFRR 176_ AFKQL 181_ DVEAA 186_ LTKAL 191_ GEVDI 196_ LLTWM 201_QKFYK
1: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity)