Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)]
1_MLLSP 6_ SLLLL 11_ LLLGA 16_ PRGCA 21_ EGVAA 26_ ALTPE 31_ RLLEW 36_ QDKGI 41_ FVIQS 46_ ESLKK 51_ CIQAG 56_ KSVLT 61_ LENCK 66_ QANKH 71_ MLWKW 76_ VSNHG 81_ LFNIG 86_ GSGCL 91_ GLNFS 96_ APEQP 101_ LSLYE 106_ CDSTL 111_ VSLRW 116_ RCNRK 121_ MITGP 126_ LQYSV 131_ QVAHD 136_ NTVVA 141_ SRKYI 146_ HKWIS 151_ YGSGG 156_ GDICE 161_ YLHKD 166_ LHTIK 171_ GNTHG 176_ MPCMF 181_ PFQYN 186_ HQWHH 191_ ECTRE 196_ GREDD 201_ LLWCA 206_ TTSRY 211_ ERDEK 216_ WGFCP 221_ DPTSA 226_ EVGCD 231_ TIWEK 236_ DLNSH 241_ ICYQF 246_ NLLSS 251_ LSWSE 256_ AHSSC 261_ QMQGG 266_ TLLSI 271_ TDETE 276_ ENFIR 281_ EHMSS 286_ KTVEV 291_ WMGLN 296_ QLDEH 301_ AGWQW 306_ SDGTP 311_ LNYLN 316_ WSPEV 321_ NFEPF 326_ VEDHC 331_ GTFSS 336_ FMPSA 341_ WRSRD 346_ CESTL 351_ PYICK 356_ KYLNH 361_ IDHEI 366_ VEKDA 371_ WKYYA 376_ THCEP 381_ GWNPY 386_ NRNCY 391_ KLQKE 396_ EKTWH 401_ EALRS 406_ CQADN 411_ SALID 416_ ITSLA 421_ EVEFL 426_ VTLLG 431_ DENAS 436_ ETWIG 441_ LSSNK 446_ IPVSF 451_ EWSND 456_ SSVIF 461_ TNWHT 466_ LEPHI 471_ FPNRS 476_ QLCVS 481_ AEQSE 486_ GHWKV 491_ KNCEE 496_ RLFYI 501_ CKKAG 506_ HVLSD 511_ AESGC 516_ QEGWE 521_ RHGGF 526_ CYKID 531_ TVLRS 536_ FDQAS 541_ SGYYC 546_ PPALV 551_ TITNR 556_ FEQAF 561_ ITSLI 566_ SSVVK 571_ MKDSY 576_ FWIAL 581_ QDQND 586_ TGEYT 591_ WKPVG 596_ QKPEP 601_ VQYTH 606_ WNTHQ 611_ PRYSG 616_ GCVAM 621_ RGRHP 626_ LGRWE 631_ VKHCR 636_ HFKAM 641_ SLCKQ 646_ PVENQ 651_ EKAEY 656_ EERWP 661_ FHPCY 666_ LDWES 671_ EPGLA 676_ SCFKV 681_ FHSEK 686_ VLMKR 691_ TWREA 696_ EAFCE 701_ EFGAH 706_ LASFA 711_ HIEEE 716_ NFVNE 721_ LLHSK 726_ FNWTE 731_ ERQFW 736_ IGFNK 741_ RNPLN 746_ AGSWE 751_ WSDRT 756_ PVVSS 761_ FLDNT 766_ YFGED 771_ ARNCA 776_ VYKAN 781_ KTLLP 786_ LHCGS 791_ KREWI 796_ CKIPR 801_ DVKPK 806_ IPFWY 811_ QYDVP 816_ WLFYQ 821_ DAEYL 826_ FHTFA 831_ SEWLN 836_ FEFVC 841_ SWLHS 846_ DLLTI 851_ HSAHE 856_ QEFIH 861_ SKIKA 866_ LSKYG 871_ ASWWI 876_ GLQEE 881_ RANDE 886_ FRWRD 891_ GTPVI 896_ YQNWD 901_ TGRER 906_ TVNNQ 911_ SQRCG 916_ FISSI 921_ TGLWG 926_ SEECS 931_ VSMPS 936_ ICKRK 941_ KVWLI 946_ EKKKD 951_ TPKQH 956_ GTCPK 961_ GWLYF 966_ NYKCL 971_ LLNIP 976_ KDPSS 981_ WKNWT 986_ HAQHF 991_ CAEEG 996_ GTLVA 1001_ IESEV 1006_ EQAFI 1011_ TMNLF 1016_ GQTTS 1021_ VWIGL 1026_ QNDDY 1031_ ETWLN 1036_ GKPVV 1041_ YSNWS 1046_ PFDII 1051_ NIPSH 1056_ NTTEV 1061_ QKHIP 1066_ LCALL 1071_ SSNPN 1076_ FHFTG 1081_ KWYFE 1086_ DCGKE 1091_ GYGFV 1096_ CEKMQ 1101_ DTSGH 1106_ GVNTS 1111_ DMYPM 1116_ PNTLE 1121_ YGNRT 1126_ YKIIN 1131_ ANMTW 1136_ YAAIK 1141_ TCLMH 1146_ KAQLV 1151_ SITDQ 1156_ YHQSF 1161_ LTVVL 1166_ NRLGY 1171_ AHWIG 1176_ LFTTD 1181_ NGLNF 1186_ DWSDG 1191_ TKSSF 1196_ TFWKD 1201_ EESSL 1206_ LGDCV 1211_ FADSN 1216_ GRWHS 1221_ TACES 1226_ FLQGA 1231_ ICHVP 1236_ PETRQ 1241_ SEHPE 1246_ LCSET 1251_ SIPWI 1256_ KFKSN 1261_ CYSFS 1266_ TVLDS 1271_ MSFEA 1276_ AHEFC 1281_ KKEGS 1286_ NLLTI 1291_ KDEAE 1296_ NAFLL 1301_ EELFA 1306_ FGSSV 1311_ QMVWL 1316_ NAQFD 1321_ GNNET 1326_ IKWFD 1331_ GTPTD 1336_ QSNWG 1341_ IRKPD 1346_ TDYFK 1351_ PHHCV 1356_ ALRIP 1361_ EGLWQ 1366_ LSPCQ 1371_ EKKGF 1376_ ICKME 1381_ ADIHT 1386_ AEALP 1391_ EKGPS 1396_ HSIIP 1401_ LAVVL 1406_ TLIVI 1411_ VAICT 1416_ LSFCI 1421_ YKHNG 1426_ GFFRR 1431_ LAGFR 1436_ NPYYP 1441_ ATNFS 1446_ TVYLE 1451_ ENILI 1456_SDLEK
1: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B (PubMed:15611272, PubMed:7721806). In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis (PubMed:25335547)