Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)]
1_MAVFR 6_ SGLLV 11_ LTTPL 16_ ASLAP 21_ RLASI 26_ LTSAA 31_ RLVNH 36_ TLYVH 41_ LQPGM 46_ SLEGP 51_ AQPQS 56_ SPVQA 61_ TFEVL 66_ DFITH 71_ LYAGA 76_ DVHRH 81_ LDVRI 86_ LLTNI 91_ RTKST 96_ FLPPL 101_ PTSVQ 106_ NLAHP 111_ PEVVL 116_ TDFQT 121_ LDGSQ 126_ YNPVK 131_ QQLVR 136_ YATSC 141_ YSCCP 146_ RLASV 151_ LLYSD 156_ YGIGE 161_ VPVEP 166_ LDVPL 171_ PSTIR 176_ PASPV 181_ AGSPK 186_ QPVRG 191_ YYRGA 196_ VGGTF 201_ DRLHN 206_ AHKVL 211_ LSVAC 216_ ILAQE 221_ QLVVG 226_ VADKD 231_ LLKSK 236_ LLPEL 241_ LQPYT 246_ ERVEH 251_ LSEFL 256_ VDIKP 261_ SLTFD 266_ VIPLL 271_ DPYGP 276_ AGSDP 281_ SLEFL 286_ VVSEE 291_ TYRGG 296_ MAINR 301_ FRLEN 306_ DLEEL 311_ ALYQI 316_ QLLKD 321_ LRHTE 326_ NEEDK 331_ VSSSS 336_ FRQRM 341_ LGNLL 346_ RPPYE 351_ RPELP 356_ TCLYV 361_ IGLTG 366_ ISGSG 371_ KSSIA 376_ QRLKG 381_ LGAFV 386_ IDSDH 391_ LGHRA 396_ YAPGG 401_ PAYQP 406_ VVEAF 411_ GTDIL 416_ HKDGI 421_ INRKV 426_ LGSRV 431_ FGNKK 436_ QLKIL 441_ TDIMW 446_ PIIAK 451_ LAREE 456_ MDRAV 461_ AEGKR 466_ VCVID 471_ AAVLL 476_ EAGWQ 481_ NLVHE 486_ VWTAV 491_ IPETE 496_ AVRRI 501_ VERDG 506_ LSEAA 511_ AQSRL 516_ QSQMS 521_ GQQLV 526_ EQSHV 531_ VLSTL 536_ WEPHI 541_ TQRQV 546_ EKAWA 551_ LLQKR 556_IPKTH
1: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation