Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)
1_MEEPA 6_ APSEA 11_ HEAAG 16_ AQAGA 21_ EAARE 26_ GVSGP 31_ DLPVC 36_ EPSGE 41_ SAAPD 46_ SALPH 51_ AARGW 56_ APFPV 61_ APVPA 66_ HLRRG 71_ GLRPA 76_ PASGG 81_ GAWPS 86_ PLPSR 91_ SSGIW 96_ TKQII 101_ CRYYI 106_ HGQCK 111_ EGENC 116_ RYSHD 121_ LSGRK 126_ MATEG 131_ GVSPP 136_ GASAG 141_ GGPST 146_ AAHIE 151_ PPTQE 156_ VAEAP 161_ PAASS 166_ LSLPV 171_ IGSAA 176_ ERGFF 181_ EAERD 186_ NADRG 191_ AAGGA 196_ GVESW 201_ ADAIE 206_ FVPGQ 211_ PYRGR 216_ WVASA 221_ PEAPL 226_ QSSET 231_ ERKQM 236_ AVGSG 241_ LRFCY 246_ YASRG 251_ VCFRG 256_ ESCMY 261_ LHGDI 266_ CDMCG 271_ LQTLH 276_ PMDAA 281_ QREEH 286_ MRACI 291_ EAHEK 296_ DMELS 301_ FAVQR 306_ GMDKV 311_ CGICM 316_ EVVYE 321_ KANPN 326_ DRRFG 331_ ILSNC 336_ NHSFC 341_ IRCIR 346_ RWRSA 351_ RQFEN 356_ RIVKS 361_ CPQCR 366_ VTSEL 371_ VIPSE 376_ FWVEE 381_ EEEKQ 386_ KLIQQ 391_ YKEAM 396_ SNKAC 401_ RYFAE 406_ GRGNC 411_ PFGDT 416_ CFYKH 421_ EYPEG 426_ WGDEP 431_ PGPGG 436_ GSFSA 441_ YWHQL 446_ VEPVR 451_ MGEGN 456_ MLYKS 461_ IKKEL 466_ VVLRL 471_ ASLLF 476_ KRFLS 481_ LRDEL 486_ PFSED 491_ QWDLL 496_ HYELE 501_EYFNL
1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Acts as a key developmental timer that helps ensure puberty begins at the appropriate age, by inhibiting premature activation of the reproductive hormone cascade. Epigenetically regulates GNRH1 transcription by disrupting the binding of methyl-DNA binding protein 3/MBD3 to the promoter of GNRH1. Mechanistically, mediates the non-proteolytic ubiquitination of MBD3 at multiple sites with 'Lys27' ubiquitin linkages and thereby regulates the methylation status of the genome, including GNRH1 promoter (PubMed:34692086). Modulates the stability and translation of GNRH1 mRNA by mediating the non-proteolytic ubiquitination of PABP family members PABPC1, PABPC3 and PABPC4 at multiple sites (PubMed:33744966). Also participates in the maintenance of genomic and epigenomic stability by regulating the abundance of APEX2 via 'Lys-48'-linked ubiquitination (PubMed:38705397)