Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)
1_MATQQ 6_ KASDE 11_ RISQF 16_ DHNLL 21_ PELSA 26_ LLGLD 31_ AVQLA 36_ KELEE 41_ EEQKE 46_ RAKMQ 51_ KGYNS 56_ QMRSE 61_ AKRLK 66_ TFVTY 71_ EPYSS 76_ WIPQE 81_ MAAAG 86_ FYFTG 91_ VKSGI 96_ QCFCC 101_ SLILF 106_ GAGLT 111_ RLPIE 116_ DHKRF 121_ HPDCG 126_ FLLNK 131_ DVGNI 136_ AKYDI 141_ RVKNL 146_ KSRLR 151_ GGKMR 156_ YQEEE 161_ ARLAS 166_ FRNWP 171_ FYVQG 176_ ISPCV 181_ LSEAG 186_ FVFTG 191_ KQDTV 196_ QCFSC 201_ GGCLG 206_ NWEEG 211_ DDPWK 216_ EHAKW 221_ FPKCE 226_ FLRSK 231_ KSSEE 236_ ITQYI 241_ QSYKG 246_ FVDIT 251_ GEHFV 256_ NSWVQ 261_ RELPM 266_ ASAYC 271_ NDSIF 276_ AYEEL 281_ RLDSF 286_ KDWPR 291_ ESAVG 296_ VAALA 301_ KAGLF 306_ YTGIK 311_ DIVQC 316_ FSCGG 321_ CLEKW 326_ QEGDD 331_ PLDDH 336_ TRCFP 341_ NCPFL 346_ QNMKS 351_ SAEVT 356_ PDLQS 361_ RGELC 366_ ELLET 371_ TSESN 376_ LEDSI 381_ AVGPI 386_ VPEMA 391_ QGEAQ 396_ WFQEA 401_ KNLNE 406_ QLRAA 411_ YTSAS 416_ FRHMS 421_ LLDIS 426_ SDLAT 431_ DHLLG 436_ CDLSI 441_ ASKHI 446_ SKPVQ 451_ EPLVL 456_ PEVFG 461_ NLNSV 466_ MCVEG 471_ EAGSG 476_ KTVLL 481_ KKIAF 486_ LWASG 491_ CCPLL 496_ NRFQL 501_ VFYLS 506_ LSSTR 511_ PDEGL 516_ ASIIC 521_ DQLLE 526_ KEGSV 531_ TEMCV 536_ RNIIQ 541_ QLKNQ 546_ VLFLL 551_ DDYKE 556_ ICSIP 561_ QVIGK 566_ LIQKN 571_ HLSRT 576_ CLLIA 581_ VRTNR 586_ ARDIR 591_ RYLET 596_ ILEIK 601_ AFPFY 606_ NTVCI 611_ LRKLF 616_ SHNMT 621_ RLRKF 626_ MVYFG 631_ KNQSL 636_ QKIQK 641_ TPLFV 646_ AAICA 651_ HWFQY 656_ PFDPS 661_ FDDVA 666_ VFKSY 671_ MERLS 676_ LRNKA 681_ TAEIL 686_ KATVS 691_ SCGEL 696_ ALKGF 701_ FSCCF 706_ EFNDD 711_ DLAEA 716_ GVDED 721_ EDLTM 726_ CLMSK 731_ FTAQR 736_ LRPFY 741_ RFLSP 746_ AFQEF 751_ LAGMR 756_ LIELL 761_ DSDRQ 766_ EHQDL 771_ GLYHL 776_ KQINS 781_ PMMTV 786_ SAYNN 791_ FLNYV 796_ SSLPS 801_ TKAGP 806_ KIVSH 811_ LLHLV 816_ DNKES 821_ LENIS 826_ ENDDY 831_ LKHQP 836_ EISLQ 841_ MQLLR 846_ GLWQI 851_ CPQAY 856_ FSMVS 861_ EHLLV 866_ LALKT 871_ AYQSN 876_ TVAAC 881_ SPFVL 886_ QFLQG 891_ RTLTL 896_ GALNL 901_ QYFFD 906_ HPESL 911_ SLLRS 916_ IHFPI 921_ RGNKT 926_ SPRAH 931_ FSVLE 936_ TCFDK 941_ SQVPT 946_ IDQDY 951_ ASAFE 956_ PMNEW 961_ ERNLA 966_ EKEDN 971_ VKSYM 976_ DMQRR 981_ ASPDL 986_ STGYW 991_ KLSPK 996_ QYKIP 1001_ CLEVD 1006_ VNDID 1011_ VVGQD 1016_ MLEIL 1021_ MTVFS 1026_ ASQRI 1031_ ELHLN 1036_ HSRGF 1041_ IESIR 1046_ PALEL 1051_ SKASV 1056_ TKCSI 1061_ SKLEL 1066_ SAAEQ 1071_ ELLLT 1076_ LPSLE 1081_ SLEVS 1086_ GTIQS 1091_ QDQIF 1096_ PNLDK 1101_ FLCLK 1106_ ELSVD 1111_ LEGNI 1116_ NVFSV 1121_ IPEEF 1126_ PNFHH 1131_ MEKLL 1136_ IQISA 1141_ EYDPS 1146_ KLVKL 1151_ IQNSP 1156_ NLHVF 1161_ HLKCN 1166_ FFSDF 1171_ GSLMT 1176_ MLVSC 1181_ KKLTE 1186_ IKFSD 1191_ SFFQA 1196_ VPFVA 1201_ SLPNF 1206_ ISLKI 1211_ LNLEG 1216_ QQFPD 1221_ EETSE 1226_ KFAYI 1231_ LGSLS 1236_ NLEEL 1241_ ILPTG 1246_ DGIYR 1251_ VAKLI 1256_ IQQCQ 1261_ QLHCL 1266_ RVLSF 1271_ FKTLN 1276_ DDSVV 1281_ EIAKV 1286_ AISGG 1291_ FQKLE 1296_ NLKLS 1301_ INHKI 1306_ TEEGY 1311_ RNFFQ 1316_ ALDNM 1321_ PNLQE 1326_ LDISR 1331_ HFTEC 1336_ IKAQA 1341_ TTVKS 1346_ LSQCV 1351_ LRLPR 1356_ LIRLN 1361_ MLSWL 1366_ LDADD 1371_ IALLN 1376_ VMKER 1381_ HPQSK 1386_ YLTIL 1391_ QKWIL 1396_PFSPI
1: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
2: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila