Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)
1_MDEPS 6_ PLAQP 11_ LELNQ 16_ HSRFI 21_ IGSVS 26_ EDNSE 31_ DEISN 36_ LVKLD 41_ LLEEK 46_ EGSLS 51_ PASVG 56_ SDTLS 61_ DLGIS 66_ SLQDG 71_ LALHI 76_ RSSMS 81_ GLHLV 86_ KQGRD 91_ RKKID 96_ SQRDF 101_ TVASP 106_ AEFVT 111_ RFGGN 116_ KVIEK 121_ VLIAN 126_ NGIAA 131_ VKCMR 136_ SIRRW 141_ SYEMF 146_ RNERA 151_ IRFVV 156_ MVTPE 161_ DLKAN 166_ AEYIK 171_ MADHY 176_ VPVPG 181_ GPNNN 186_ NYANV 191_ ELILD 196_ IAKRI 201_ PVQAV 206_ WAGWG 211_ HASEN 216_ PKLPE 221_ LLLKN 226_ GIAFM 231_ GPPSQ 236_ AMWAL 241_ GDKIA 246_ SSIVA 251_ QTAGI 256_ PTLPW 261_ SGSGL 266_ RVDWQ 271_ ENDFS 276_ KRILN 281_ VPQEL 286_ YEKGY 291_ VKDVD 296_ DGLQA 301_ AEEVG 306_ YPVMI 311_ KASEG 316_ GGGKG 321_ IRKVN 326_ NADDF 331_ PNLFR 336_ QVQAE 341_ VPGSP 346_ IFVMR 351_ LAKQS 356_ RHLEV 361_ QILAD 366_ QYGNA 371_ ISLFG 376_ RDCSV 381_ QRRHQ 386_ KIIEE 391_ APATI 396_ ATPAV 401_ FEHME 406_ QCAVK 411_ LAKMV 416_ GYVSA 421_ GTVEY 426_ LYSQD 431_ GSFYF 436_ LELNP 441_ RLQVE 446_ HPCTE 451_ MVADV 456_ NLPAA 461_ QLQIA 466_ MGIPL 471_ YRIKD 476_ IRMMY 481_ GVSPW 486_ GDSPI 491_ DFEDS 496_ AHVPC 501_ PRGHV 506_ IAARI 511_ TSENP 516_ DEGFK 521_ PSSGT 526_ VQELN 531_ FRSNK 536_ NVWGY 541_ FSVAA 546_ AGGLH 551_ EFADS 556_ QFGHC 561_ FSWGE 566_ NREEA 571_ ISNMV 576_ VALKE 581_ LSIRG 586_ DFRTT 591_ VEYLI 596_ KLLET 601_ ESFQM 606_ NRIDT 611_ GWLDR 616_ LIAEK 621_ VQAER 626_ PDTML 631_ GVVCG 636_ ALHVA 641_ DVSLR 646_ NSVSN 651_ FLHSL 656_ ERGQV 661_ LPAHT 666_ LLNTV 671_ DVELI 676_ YEGVK 681_ YVLKV 686_ TRQSP 691_ NSYVV 696_ IMNGS 701_ CVEVD 706_ VHRLS 711_ DGGLL 716_ LSYDG 721_ SSYTT 726_ YMKEE 731_ VDRYR 736_ ITIGN 741_ KTCVF 746_ EKEND 751_ PSVMR 756_ SPSAG 761_ KLIQY 766_ IVEDG 771_ GHVFA 776_ GQCYA 781_ EIEVM 786_ KMVMT 791_ LTAVE 796_ SGCIH 801_ YVKRP 806_ GAALD 811_ PGCVL 816_ AKMQL 821_ DNPSK 826_ VQQAE 831_ LHTGS 836_ LPRIQ 841_ STALR 846_ GEKLH 851_ RVFHY 856_ VLDNL 861_ VNVMN 866_ GYCLP 871_ DPFFS 876_ SKVKD 881_ WVERL 886_ MKTLR 891_ DPSLP 896_ LLELQ 901_ DIMTS 906_ VSGRI 911_ PPNVE 916_ KSIKK 921_ EMAQY 926_ ASNIT 931_ SVLCQ 936_ FPSQQ 941_ IANIL 946_ DSHAA 951_ TLNRK 956_ SEREV 961_ FFMNT 966_ QSIVQ 971_ LVQRY 976_ RSGIR 981_ GHMKA 986_ VVMDL 991_ LRQYL 996_ RVETQ 1001_ FQNGH 1006_ YDKCV 1011_ FALRE 1016_ ENKSD 1021_ MNTVL 1026_ NYIFS 1031_ HAQVT 1036_ KKNLL 1041_ VTMLI 1046_ DQLCG 1051_ RDPTL 1056_ TDELL 1061_ NILTE 1066_ LTQLS 1071_ KTTNA 1076_ KVALR 1081_ ARQVL 1086_ IASHL 1091_ PSYEL 1096_ RHNQV 1101_ ESIFL 1106_ SAIDM 1111_ YGHQF 1116_ CIENL 1121_ QKLIL 1126_ SETSI 1131_ FDVLP 1136_ NFFYH 1141_ SNQVV 1146_ RMAAL 1151_ EVYVR 1156_ RAYIA 1161_ YELNS 1166_ VQHRQ 1171_ LKDNT 1176_ CVVEF 1181_ QFMLP 1186_ TSHPN 1191_ RGNIP 1196_ TLNRM 1201_ SFSSN 1206_ LNHYG 1211_ MTHVA 1216_ SVSDV 1221_ LLDNS 1226_ FTPPC 1231_ QRMGG 1236_ MVSFR 1241_ TFEDF 1246_ VRIFD 1251_ EVMGC 1256_ FSDSP 1261_ PQSPT 1266_ FPEAG 1271_ HTSLY 1276_ DEDKV 1281_ PRDEP 1286_ IHILN 1291_ VAIKT 1296_ DCDIE 1301_ DDRLA 1306_ AMFRE 1311_ FTQQN 1316_ KATLV 1321_ DHGIR 1326_ RLTFL 1331_ VAQKD 1336_ FRKQV 1341_ NYEVD 1346_ RRFHR 1351_ EFPKF 1356_ FTFRA 1361_ RDKFE 1366_ EDRIY 1371_ RHLEP 1376_ ALAFQ 1381_ LELNR 1386_ MRNFD 1391_ LTAIP 1396_ CANHK 1401_ MHLYL 1406_ GAAKV 1411_ EVGTE 1416_ VTDYR 1421_ FFVRA 1426_ IIRHS 1431_ DLVTK 1436_ EASFE 1441_ YLQNE 1446_ GERLL 1451_ LEAMD 1456_ ELEVA 1461_ FNNTN 1466_ VRTDC 1471_ NHIFL 1476_ NFVPT 1481_ VIMDP 1486_ SKIEE 1491_ SVRSM 1496_ VMRYG 1501_ SRLWK 1506_ LRVLQ 1511_ AELKI 1516_ NIRLT 1521_ PTGKA 1526_ IPIRL 1531_ FLTNE 1536_ SGYYL 1541_ DISLY 1546_ KEVTD 1551_ SRTAQ 1556_ IMFQA 1561_ YGDKQ 1566_ GPLHG 1571_ MLINT 1576_ PYVTK 1581_ DLLQS 1586_ KRFQA 1591_ QSLGT 1596_ TYIYD 1601_ IPEMF 1606_ RQSLI 1611_ KLWES 1616_ MSTQA 1621_ FLPSP 1626_ PLPSD 1631_ MLTYT 1636_ ELVLD 1641_ DQGQL 1646_ VHMNR 1651_ LPGGN 1656_ EIGMV 1661_ AWKMT 1666_ FKSPE 1671_ YPEGR 1676_ DIIVI 1681_ GNDIT 1686_ YRIGS 1691_ FGPQE 1696_ DLLFL 1701_ RASEL 1706_ ARAEG 1711_ IPRIY 1716_ VSANS 1721_ GARIG 1726_ LAEEI 1731_ RHMFH 1736_ VAWVD 1741_ PEDPY 1746_ KGYRY 1751_ LYLTP 1756_ QDYKR 1761_ VSALN 1766_ SVHCE 1771_ HVEDE 1776_ GESRY 1781_ KITDI 1786_ IGKEE 1791_ GIGPE 1796_ NLRGS 1801_ GMIAG 1806_ ESSLA 1811_ YNEII 1816_ TISLV 1821_ TCRAI 1826_ GIGAY 1831_ LVRLG 1836_ QRTIQ 1841_ VENSH 1846_ LILTG 1851_ AGALN 1856_ KVLGR 1861_ EVYTS 1866_ NNQLG 1871_ GIQIM 1876_ HNNGV 1881_ THCTV 1886_ CDDFE 1891_ GVFTV 1896_ LHWLS 1901_ YMPKS 1906_ VHSSV 1911_ PLLNS 1916_ KDPID 1921_ RIIEF 1926_ VPTKT 1931_ PYDPR 1936_ WMLAG 1941_ RPHPT 1946_ QKGQW 1951_ LSGFF 1956_ DYGSF 1961_ SEIMQ 1966_ PWAQT 1971_ VVVGR 1976_ ARLGG 1981_ IPVGV 1986_ VAVET 1991_ RTVEL 1996_ SIPAD 2001_ PANLD 2006_ SEAKI 2011_ IQQAG 2016_ QVWFP 2021_ DSAFK 2026_ TYQAI 2031_ KDFNR 2036_ EGLPL 2041_ MVFAN 2046_ WRGFS 2051_ GGMKD 2056_ MYDQV 2061_ LKFGA 2066_ YIVDG 2071_ LRECC 2076_ QPVLV 2081_ YIPPQ 2086_ AELRG 2091_ GSWVV 2096_ IDSSI 2101_ NPRHM 2106_ EMYAD 2111_ RESRG 2116_ SVLEP 2121_ EGTVE 2126_ IKFRR 2131_ KDLVK 2136_ TMRRV 2141_ DPVYI 2146_ HLAER 2151_ LGTPE 2156_ LSTAE 2161_ RKELE 2166_ NKLKE 2171_ REEFL 2176_ IPIYH 2181_ QVAVQ 2186_ FADLH 2191_ DTPGR 2196_ MQEKG 2201_ VISDI 2206_ LDWKT 2211_ SRTFF 2216_ YWRLR 2221_ RLLLE 2226_ DLVKK 2231_ KIHNA 2236_ NPELT 2241_ DGQIQ 2246_ AMLRR 2251_ WFVEV 2256_ EGTVK 2261_ AYVWD 2266_ NNKDL 2271_ AEWLE 2276_ KQLTE 2281_ EDGVH 2286_ SVIEE 2291_ NIKCI 2296_ SRDYV 2301_ LKQIR 2306_ SLVQA 2311_ NPEVA 2316_ MDSII 2321_ HMTQH 2326_ ISPTQ 2331_ RAEVI 2336_ RILST 2341_MDSPS
1: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443)