Protein disulfide-isomerase A2 (EC 5.3.4.1) (Pancreas-specific protein disulfide isomerase) (PDIp)
1_MSRQL 6_ LPVLL 11_ LLLLR 16_ ASCPW 21_ GQEQG 26_ ARSPS 31_ EEPPE 36_ EEIPK 41_ EDGIL 46_ VLSRH 51_ TLGLA 56_ LREHP 61_ ALLVE 66_ FYAPW 71_ CGHCQ 76_ ALAPE 81_ YSKAA 86_ AVLAA 91_ ESMVV 96_ TLAKV 101_ DGPAQ 106_ RELAE 111_ EFGVT 116_ EYPTL 121_ KFFRN 126_ GNRTH 131_ PEEYT 136_ GPRDA 141_ EGIAE 146_ WLRRR 151_ VGPSA 156_ MRLED 161_ EAAAQ 166_ ALIGG 171_ RDLVV 176_ IGFFQ 181_ DLQDE 186_ DVATF 191_ LALAQ 196_ DALDM 201_ TFGLT 206_ DRPRL 211_ FQQFG 216_ LTKDT 221_ VVLFK 226_ KFDEG 231_ RADFP 236_ VDEEL 241_ GLDLG 246_ DLSRF 251_ LVTHS 256_ MRLVT 261_ EFNSQ 266_ TSAKI 271_ FAARI 276_ LNHLL 281_ LFVNQ 286_ TLAAH 291_ RELLA 296_ GFGEA 301_ APRFR 306_ GQVLF 311_ VVVDV 316_ AADNE 321_ HVLQY 326_ FGLKA 331_ EAAPT 336_ LRLVN 341_ LETTK 346_ KYAPV 351_ DGGPV 356_ TAASI 361_ TAFCH 366_ AVLNG 371_ QVKPY 376_ LLSQE 381_ IPPDW 386_ DQRPV 391_ KTLVG 396_ KNFEQ 401_ VAFDE 406_ TKNVF 411_ VKFYA 416_ PWCTH 421_ CKEMA 426_ PAWEA 431_ LAEKY 436_ QDHED 441_ IIIAE 446_ LDATA 451_ NELDA 456_ FAVHG 461_ FPTLK 466_ YFPAG 471_ PGRKV 476_ IEYKS 481_ TRDLE 486_ TFSKF 491_ LDNGG 496_ VLPTE 501_ EPPEE 506_ PAAPF 511_ PEPPA 516_NSTMG
1: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins