Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)
1_MVPPK 6_ LHVLF 11_ CLCGC 16_ LAVVY 21_ PFDWQ 26_ YINPV 31_ AHMKS 36_ SAWVN 41_ KIQVL 46_ MAAAS 51_ FGQTK 56_ IPRGN 61_ GPYSV 66_ GCTDL 71_ MFDHT 76_ NKGTF 81_ LRLYY 86_ PSQDN 91_ DRLDT 96_ LWIPN 101_ KEYFW 106_ GLSKF 111_ LGTHW 116_ LMGNI 121_ LRLLF 126_ GSMTT 131_ PANWN 136_ SPLRP 141_ GEKYP 146_ LVVFS 151_ HGLGA 156_ FRTLY 161_ SAIGI 166_ DLASH 171_ GFIVA 176_ AVEHR 181_ DRSAS 186_ ATYYF 191_ KDQSA 196_ AEIGD 201_ KSWLY 206_ LRTLK 211_ QEEET 216_ HIRNE 221_ QVRQR 226_ AKECS 231_ QALSL 236_ ILDID 241_ HGKPV 246_ KNALD 251_ LKFDM 256_ EQLKD 261_ SIDRE 266_ KIAVI 271_ GHSFG 276_ GATVI 281_ QTLSE 286_ DQRFR 291_ CGIAL 296_ DAWMF 301_ PLGDE 306_ VYSRI 311_ PQPLF 316_ FINSE 321_ YFQYP 326_ ANIIK 331_ MKKCY 336_ SPDKE 341_ RKMIT 346_ IRGSV 351_ HQNFA 356_ DFTFA 361_ TGKII 366_ GHMLK 371_ LKGDI 376_ DSNVA 381_ IDLSN 386_ KASLA 391_ FLQKH 396_ LGLHK 401_ DFDQW 406_ DCLIE 411_ GDDEN 416_ LIPGT 421_ NINTT 426_ NQHIM 431_ LQNSS 436_GIEKY
1: Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:16371369, PubMed:17090529, PubMed:2040620, PubMed:7700381, PubMed:8624782). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10504265, PubMed:2040620). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10066756, PubMed:10504265, PubMed:11590221, PubMed:16371369, PubMed:18434304, PubMed:7592717, PubMed:7700381, PubMed:8624782, PubMed:8675689). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369)