Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
1_MALRN 6_ VPFRS 11_ EVLGW 16_ DPDSL 21_ ADYFK 26_ KLNYK 31_ DCEKA 36_ VKKYH 41_ IDGAR 46_ FLNLT 51_ ENDIQ 56_ KFPKL 61_ RVPIL 66_ SKLSQ 71_ EINKN 76_ EERRS 81_ IFTRK 86_ PQVPR 91_ FPEET 96_ ESHEE 101_ DNGGW 106_ SSFEE 111_ DDYES 116_ PNDDQ 121_ DGEDD 126_ GDYES 131_ PNEEE 136_ EAPVE 141_ DDADY 146_ EPPPS 151_ NDEEA 156_ LQNSI 161_ LPAKP 166_ FPNSN 171_ SMYID 176_ RPPSG 181_ KTPQQ 186_ PPVPP 191_ QRPMA 196_ ALPPP 201_ PAGRN 206_ HSPLP 211_ PPQTN 216_ HEEPS 221_ RSRNH 226_ KTAKL 231_ PAPSI 236_ DRSTK 241_ PPLDR 246_ SLAPF 251_ DREPF 256_ TLGKK 261_ PPFSD 266_ KPSIP 271_ AGRSL 276_ GEHLP 281_ KIQKP 286_ PLPPT 291_ TERHE 296_ RSSPL 301_ PGKKP 306_ PVPKH 311_ GWGPD 316_ RREND 321_ EDDVH 326_ QRPLP 331_ QPALL 336_ PMSSN 341_ TFPSR 346_ STKPS 351_ PMNPL 356_ PSSHM 361_ PGAFS 366_ ESNSS 371_ FPQSA 376_ SLPPY 381_ FSQGP 386_ SNRPP 391_ IRAEG 396_ RNFPL 401_ PLPNK 406_ PRPPS 411_ PAEEE 416_ NSLNE 421_ EWYVS 426_ YITRP 431_ EAEAA 436_ LRKIN 441_ QDGTF 446_ LVRDS 451_ SKKTT 456_ TNPYV 461_ LMVLY 466_ KDKVY 471_ NIQIR 476_ YQKES 481_ QVYLL 486_ GTGLR 491_ GKEDF 496_ LSVSD 501_ IIDYF 506_ RKMPL 511_ LLIDG 516_ KNRGS 521_ RYQCT 526_LTHAA
1: Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632)