COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)
1_MPLPV 6_ QVFNL 11_ QGAVE 16_ PMQID 21_ VDPQE 26_ DPQNA 31_ PDVNY 36_ VVENP 41_ SLDLE 46_ QYAAS 51_ YSGLM 56_ RIERL 61_ QFIAD 66_ HCPTL 71_ RVEAL 76_ KMALS 81_ FVQRT 86_ FNVDM 91_ YEEIH 96_ RKLSE 101_ ATRSS 106_ LRELQ 111_ NAPDA 116_ IPESG 121_ VEPPA 126_ LDTAW 131_ VEATR 136_ KKALL 141_ KLEKL 146_ DTDLK 151_ NYKGN 156_ SIKES 161_ IRRGH 166_ DDLGD 171_ HYLDC 176_ GDLSN 181_ ALKCY 186_ SRARD 191_ YCTSA 196_ KHVIN 201_ MCLNV 206_ IKVSV 211_ YLQNW 216_ SHVLS 221_ YVSKA 226_ ESTPE 231_ IAEQR 236_ GERDS 241_ QTQAI 246_ LTKLK 251_ CAAGL 256_ AELAA 261_ RKYKQ 266_ AAKCL 271_ LLASF 276_ DHCDF 281_ PELLS 286_ PSNVA 291_ IYGGL 296_ CALAT 301_ FDRQE 306_ LQRNV 311_ ISSSS 316_ FKLFL 321_ ELEPQ 326_ VRDII 331_ FKFYE 336_ SKYAS 341_ CLKML 346_ DEMKD 351_ NLLLD 356_ MYLAP 361_ HVRTL 366_ YTQIR 371_ NRALI 376_ QYFSP 381_ YVSAD 386_ MHRMA 391_ AAFNT 396_ TVAAL 401_ EDELT 406_ QLILE 411_ GLISA 416_ RVDSH 421_ SKILY 426_ ARDVD 431_ QRSTT 436_ FEKSL 441_ LMGKE 446_ FQRRA 451_ KAMML 456_ RAAVL 461_ RNQIH 466_ VKSPP 471_ REGSQ 476_ GELTP 481_ ANSQS 486_RMSTN
1: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction