Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
1_MAEGG 6_ GCRER 11_ PDAET 16_ QKSEL 21_ GPLMR 26_ TTLQR 31_ GAQWY 36_ LIDSR 41_ WFKQW 46_ KKYVG 51_ FDSWD 56_ MYNVG 61_ EHNLF 66_ PGPID 71_ NSGLF 76_ SDPES 81_ QTLKE 86_ HLIDE 91_ LDYVL 96_ VPTEA 101_ WNKLL 106_ NWYGC 111_ VEGQQ 116_ PIVRK 121_ VVEHG 126_ LFVKH 131_ CKVEV 136_ YLLEL 141_ KLCEN 146_ SDPTN 151_ VLSCH 156_ FSKAD 161_ TIATI 166_ EKEMR 171_ KLFNI 176_ PAERE 181_ TRLWN 186_ KYMSN 191_ TYEQL 196_ SKLDN 201_ TVQDA 206_ GLYQG 211_ QVLVI 216_ EPQNE 221_ DGTWP 226_ RQTLQ 231_ SKSST 236_ APSRN 241_ FTTSP 246_ KSSAS 251_ PYSSV 256_ SASLI 261_ ANGDS 266_ TSTCG 271_ MHSSG 276_ VSRGG 281_ SGFSA 286_ SYNCQ 291_ EPPSS 296_ HIQPG 301_ LCGLG 306_ NLGNT 311_ CFMNS 316_ ALQCL 321_ SNTAP 326_ LTDYF 331_ LKDEY 336_ EAEIN 341_ RDNPL 346_ GMKGE 351_ IAEAY 356_ AELIK 361_ QMWSG 366_ RDAHV 371_ APRMF 376_ KTQVG 381_ RFAPQ 386_ FSGYQ 391_ QQDSQ 396_ ELLAF 401_ LLDGL 406_ HEDLN 411_ RVKKK 416_ PYLEL 421_ KDANG 426_ RPDAV 431_ VAKEA 436_ WENHR 441_ LRNDS 446_ VIVDT 451_ FHGLF 456_ KSTLV 461_ CPECA 466_ KVSVT 471_ FDPFC 476_ YLTLP 481_ LPLKK 486_ DRVME 491_ VFLVP 496_ ADPHC 501_ RPTQY 506_ RVTVP 511_ LMGAV 516_ SDLCE 521_ ALSRL 526_ SGIAA 531_ ENMVV 536_ ADVYN 541_ HRFHK 546_ IFQMD 551_ EGLNH 556_ IMPRD 561_ DIFVY 566_ EVCST 571_ SVDGS 576_ ECVTL 581_ PVYFR 586_ ERKSR 591_ PSSTS 596_ SASAL 601_ YGQPL 606_ LLSVP 611_ KHKLT 616_ LESLY 621_ QAVCD 626_ RISRY 631_ VKQPL 636_ PDEFG 641_ SSPLE 646_ PGACN 651_ GSRNS 656_ CEGED 661_ EEEME 666_ HQEEG 671_ KEQLS 676_ ETEGS 681_ GEDEP 686_ GNDPS 691_ ETTQK 696_ KIKGQ 701_ PCPKR 706_ LFTFS 711_ LVNSY 716_ GTADI 721_ NSLAA 726_ DGKLL 731_ KLNSR 736_ STLAM 741_ DWDSE 746_ TRRLY 751_ YDEQE 756_ SEAYE 761_ KHVSM 766_ LQPQK 771_ KKKTT 776_ VALRD 781_ CIELF 786_ TTMET 791_ LGEHD 796_ PWYCP 801_ NCKKH 806_ QQATK 811_ KFDLW 816_ SLPKI 821_ LVVHL 826_ KRFSY 831_ NRYWR 836_ DKLDT 841_ VVEFP 846_ IRGLN 851_ MSEFV 856_ CNLSA 861_ RPYVY 866_ DLIAV 871_ SNHYG 876_ AMGVG 881_ HYTAY 886_ AKNKL 891_ NGKWY 896_ YFDDS 901_ NVSLA 906_ SEDQI 911_ VTKAA 916_ YVLFY 921_ QRRDD 926_ EFYKT 931_ PSLSS 936_ SGSSD 941_ GGTRP 946_ SSSQQ 951_ GFGDD 956_EACSM
1: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16339847, PubMed:16472766, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766, PubMed:30514904). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (PubMed:30514904). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847)