Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)
1_MLNFG 6_ ASLQQ 11_ TAEER 16_ MEMIS 21_ ERPKE 26_ SMYSW 31_ NKTAE 36_ KSDFE 41_ AVEAL 46_ MSMSC 51_ SWKSD 56_ FKKYV 61_ ENRPV 66_ TPVSD 71_ LSEEE 76_ NLLPG 81_ TPDFH 86_ TIPAF 91_ CLTPP 96_ YSPSD 101_ FEPSQ 106_ VSNLM 111_ APAPS 116_ TVHFK 121_ SLSDT 126_ AKPHI 131_ AAPFK 136_ EEEKS 141_ PVSAP 146_ KLPKA 151_ QATSV 156_ IRHTA 161_ DAQLC 166_ NHQTC 171_ PMKAA 176_ SILNY 181_ QNNSF 186_ RRRTH 191_ LNVEA 196_ ARKNI 201_ PCAAV 206_ SPNRS 211_ KCERN 216_ TVADV 221_ DEKAS 226_ AALYD 231_ FSVPS 236_ SETVI 241_ CRSQP 246_ APVSP 251_ QQKSV 256_ LVSPP 261_ AVSAG 266_ GVPPM 271_ PVICQ 276_ MVPLP 281_ ANNPV 286_ VTTVV 291_ PSTPP 296_ SQPPA 301_ VCPPV 306_ VFMGT 311_ QVPKG 316_ AVMFV 321_ VPQPV 326_ VQSSK 331_ PPVVS 336_ PNGTR 341_ LSPIA 346_ PAPGF 351_ SPSAA 356_ KVTPQ 361_ IDSSR 366_ IRSHI 371_ CSHPG 376_ CGKTY 381_ FKSSH 386_ LKAHT 391_ RTHTG 396_ EKPFS 401_ CSWKG 406_ CERRF 411_ ARSDE 416_ LSRHR 421_ RTHTG 426_ EKKFA 431_ CPMCD 436_ RRFMR 441_ SDHLT 446_ KHARR 451_ HLSAK 456_ KLPNW 461_ QMEVS 466_ KLNDI 471_ALPPT
1: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation