Protein Red (Cytokine IK) (IK factor) (Protein RER)
1_MPERD 6_ SEPFS 11_ NPLAP 16_ DGHDV 21_ DDPHS 26_ FHQSK 31_ LTNED 36_ FRKLL 41_ MTPRA 46_ APTSA 51_ PPSKS 56_ RHHEM 61_ PREYN 66_ EDEDP 71_ AARRR 76_ KKKSY 81_ YAKLR 86_ QQEIE 91_ REREL 96_ AEKYR 101_ DRAKE 106_ RRDGV 111_ NKDYE 116_ ETELI 121_ STTAN 126_ YRAVG 131_ PTAEA 136_ DKSAA 141_ EKRRQ 146_ LIQES 151_ KFLGG 156_ DMEHT 161_ HLVKG 166_ LDFAL 171_ LQKVR 176_ AEIAS 181_ KEKEE 186_ EELME 191_ KPQKE 196_ TKKDE 201_ DPENK 206_ IEFKT 211_ RLGRN 216_ VYRML 221_ FKSKA 226_ YERNE 231_ LFLPG 236_ RMAYV 241_ VDLDD 246_ EYADT 251_ DIPTT 256_ LIRSK 261_ ADCPT 266_ MEAQT 271_ TLTTN 276_ DIVIS 281_ KLTQI 286_ LSYLR 291_ QGTRN 296_ KKLKK 301_ KDKGK 306_ LEEKK 311_ PPEAD 316_ MNIFE 321_ DIGDY 326_ VPSTT 331_ KTPRD 336_ KERER 341_ YRERE 346_ RDRER 351_ DRDRD 356_ RERER 361_ ERDRE 366_ RERER 371_ DRERE 376_ EEKKR 381_ HSYFE 386_ KPKVD 391_ DEPMD 396_ VDKGP 401_ GSTKE 406_ LIKSI 411_ NEKFA 416_ GSAGW 421_ EGTES 426_ LKKPE 431_ DKKQL 436_ GDFFG 441_ MSNSY 446_ AECYP 451_ ATMDD 456_ MAVDS 461_ DEEVD 466_ YSKMD 471_ QGNKK 476_ GPLGR 481_ WDFDT 486_ QEEYS 491_ EYMNN 496_ KEALP 501_ KAAFQ 506_ YGIKM 511_ SEGRK 516_ TRRFK 521_ ETNDK 526_ AELDR 531_ QWKKI 536_ SAIIE 541_ KRKKM 546_ EADGV 551_EVKRP
1: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353)
2: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles