S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)
1_MASGT 6_ TTTAV 11_ KIGII 16_ GGTGL 21_ DDPEI 26_ LEGRT 31_ EKYVD 36_ TPFGK 41_ PSDAL 46_ ILGKI 51_ KNVDC 56_ VLLAR 61_ HGRQH 66_ TIMPS 71_ KVNYQ 76_ ANIWA 81_ LKEEG 86_ CTHVI 91_ VTTAC 96_ GSLRE 101_ EIQPG 106_ DIVII 111_ DQFID 116_ RTTMR 121_ PQSFY 126_ DGSHS 131_ CARGV 136_ CHIPM 141_ AEPFC 146_ PKTRE 151_ VLIET 156_ AKKLG 161_ LRCHS 166_ KGTMV 171_ TIEGP 176_ RFSSR 181_ AESFM 186_ FRTWG 191_ ADVIN 196_ MTTVP 201_ EVVLA 206_ KEAGI 211_ CYASI 216_ AMATD 221_ YDCWK 226_ EHEEA 231_ VSVDR 236_ VLKTL 241_ KENAN 246_ KAKSL 251_ LLTTI 256_ PQIGS 261_ TEWSE 266_ TLHNL 271_ KNMAQ 276_FSVLL
1: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates