Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
1_MSLWL 6_ GAPVP 11_ DIPPD 16_ SAVEL 21_ WKPGA 26_ QDASS 31_ QAQGG 36_ SSCIL 41_ REEAR 46_ MPHSA 51_ GGTAG 56_ VGLEA 61_ AEPTA 66_ LLTRA 71_ EPPSE 76_ PTEIR 81_ PQKRK 86_ KGPAP 91_ KMLGN 96_ ELCSV 101_ CGDKA 106_ SGFHY 111_ NVLSC 116_ EGCKG 121_ FFRRS 126_ VIKGA 131_ HYICH 136_ SGGHC 141_ PMDTY 146_ MRRKC 151_ QECRL 156_ RKCRQ 161_ AGMRE 166_ ECVLS 171_ EEQIR 176_ LKKLK 181_ RQEEE 186_ QAHAT 191_ SLPPR 196_ ASSPP 201_ QILPQ 206_ LSPEQ 211_ LGMIE 216_ KLVAA 221_ QQQCN 226_ RRSFS 231_ DRLRV 236_ TPWPM 241_ APDPH 246_ SREAR 251_ QQRFA 256_ HFTEL 261_ AIVSV 266_ QEIVD 271_ FAKQL 276_ PGFLQ 281_ LSRED 286_ QIALL 291_ KTSAI 296_ EVMLL 301_ ETSRR 306_ YNPGS 311_ ESITF 316_ LKDFS 321_ YNRED 326_ FAKAG 331_ LQVEF 336_ INPIF 341_ EFSRA 346_ MNELQ 351_ LNDAE 356_ FALLI 361_ AISIF 366_ SADRP 371_ NVQDQ 376_ LQVER 381_ LQHTY 386_ VEALH 391_ AYVSI 396_ HHPHD 401_ RLMFP 406_ RMLMK 411_ LVSLR 416_ TLSSV 421_ HSEQV 426_ FALRL 431_ QDKKL 436_ PPLLS 441_EIWDV
1: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (PubMed:37478846). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity)