Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
1_MEETI 6_ KDPPT 11_ SAVLL 16_ DHCHF 21_ SQVIF 26_ NSVEK 31_ FYIPG 36_ GDVTC 41_ HYTFT 46_ QHFIP 51_ RRKDW 56_ IGIFR 61_ VGWKT 66_ TREYY 71_ TFMWV 76_ TLPID 81_ LNNKS 86_ AKQQE 91_ VQFKA 96_ YYLPK 101_ DDEYY 106_ QFCYV 111_ DEDGV 116_ VRGAS 121_ IPFQF 126_ RPENE 131_ EDILV 136_ VTTQG 141_ EVEEI 146_ EQHNK 151_ ELCKE 156_ NQELK 161_ DSCIS 166_ LQKQN 171_ SDMQA 176_ ELQKK 181_ QEELE 186_ TLQSI 191_ NKKLE 196_ LKVKE 201_ QKDYW 206_ ETELL 211_ QLKEQ 216_ NQKMS 221_ SENEK 226_ MGIRV 231_ DQLQA 236_ QLSTQ 241_ EKEME 246_ KLVQG 251_ DQDKT 256_ EQLEQ 261_ LKKEN 266_ DHLFL 271_ SLTEQ 276_ RKDQK 281_ KLEQT 286_ VEQMK 291_ QNETT 296_ AMKKQ 301_ QELMD 306_ ENFDL 311_ SKRLS 316_ ENEII 321_ CNALQ 326_ RQKER 331_ LEGEN 336_ DLLKR 341_ ENSRL 346_ LSYMG 351_ LDFNS 356_ LPYQV 361_ PTSDE 366_ GGARQ 371_ NPGLA 376_ YGNPY 381_ SGIQE 386_ SSSPS 391_ PLSIK 396_ KCPIC 401_ KADDI 406_ CDHTL 411_ EQQQM 416_ QPLCF 421_ NCPIC 426_ DKIFP 431_ ATEKQ 436_ IFEDH 441_VFCHS
1: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994)