Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)
1_MAAPV 6_ VAPPG 11_ VVVSR 16_ ANKRS 21_ GAGPG 26_ GSGGG 31_ GARGA 36_ EEEPP 41_ PPLQA 46_ VLVAD 51_ SFDRR 56_ FFPIS 61_ KDQPR 66_ VLLPL 71_ ANVAL 76_ IDYTL 81_ EFLTA 86_ TGVQE 91_ TFVFC 96_ CWKAA 101_ QIKEH 106_ LLKSK 111_ WCRPT 116_ SLNVV 121_ RIITS 126_ ELYRS 131_ LGDVL 136_ RDVDA 141_ KALVR 146_ SDFLL 151_ VYGDV 156_ ISNIN 161_ ITRAL 166_ EEHRL 171_ RRKLE 176_ KNVSV 181_ MTMIF 186_ KESSP 191_ SHPTR 196_ CHEDN 201_ VVVAV 206_ DSTTN 211_ RVLHF 216_ QKTQG 221_ LRRFA 226_ FPLSL 231_ FQGSS 236_ DGVEV 241_ RYDLL 246_ DCHIS 251_ ICSPQ 256_ VAQLF 261_ TDNFD 266_ YQTRD 271_ DFVRG 276_ LLVNE 281_ EILGN 286_ QIHMH 291_ VTAKE 296_ YGARV 301_ SNLHM 306_ YSAVC 311_ ADVIR 316_ RWVYP 321_ LTPEA 326_ NFTDS 331_ TTQSC 336_ THSRH 341_ NIYRG 346_ PEVSL 351_ GHGSI 356_ LEENV 361_ LLGSG 366_ TVIGS 371_ NCFIT 376_ NSVIG 381_ PGCHI 386_ GDNVV 391_ LDQTY 396_ LWQGV 401_ RVAAG 406_ AQIHQ 411_ SLLCD 416_ NAEVK 421_ ERVTL 426_ KPRSV 431_ LTSQV 436_ VVGPN 441_ ITLPE 446_ GSVIS 451_ LHPPD 456_ AEEDE 461_ DDGEF 466_ SDDSG 471_ ADQEK 476_ DKVKM 481_ KGYNP 486_ AEVGA 491_ AGKGY 496_ LWKAA 501_ GMNME 506_ EEEEL 511_ QQNLW 516_ GLKIN 521_ MEEES 526_ ESESE 531_ QSMDS 536_ EEPDS 541_ RGGSP 546_ QMDDI 551_ KVFQN 556_ EVLGT 561_ LQRGK 566_ EENIS 571_ CDNLV 576_ LEINS 581_ LKYAY 586_ NISLK 591_ EVMQV 596_ LSHVV 601_ LEFPL 606_ QQMDS 611_ PLDSS 616_ RYCAL 621_ LLPLL 626_ KAWSP 631_ VFRNY 636_ IKRAA 641_ DHLEA 646_ LAAIE 651_ DFFLE 656_ HEALG 661_ ISMAK 666_ VLMAF 671_ YQLEI 676_ LAEET 681_ ILSWF 686_ SQRDT 691_ TDKGQ 696_ QLRKN 701_ QQLQR 706_ FIQWL 711_ KEAEE 716_ESSED
1: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)