Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)
1_MSKSG 6_ FGSYG 11_ SISAA 16_ DGASG 21_ GSDQL 26_ CERDA 31_ TPAIK 36_ TQRPK 41_ VRIQD 46_ VVPCN 51_ VNQLL 56_ SSTVF 61_ DPVFK 66_ VRGII 71_ VSQVS 76_ IVGVI 81_ RGAEK 86_ ASNHI 91_ CYKID 96_ DMTAK 101_ PIEAR 106_ QWFGR 111_ EKVKQ 116_ VTPLS 121_ VGVYV 126_ KVFGI 131_ LKCPT 136_ GTKSL 141_ EVLKI 146_ HVLED 151_ MNEFT 156_ VHILE 161_ TVNAH 166_ MMLDK 171_ ARRDT 176_ TVESV 181_ PVSPS 186_ EVNDA 191_ GDNDE 196_ SHRNF 201_ IQDEV 206_ LRLIH 211_ ECPHQ 216_ EGKSI 221_ HELRA 226_ QLCDL 231_ SVKAI 236_ KEAID 241_ YLTVE 246_ GHIYP 251_ TVDRE 256_HFKSA
1: As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange