FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
1_MDPFL 6_ VLLHS 11_ VSSSL 16_ SSSEL 21_ TELKF 26_ LCLGR 31_ VGKRK 36_ LERVQ 41_ SGLDL 46_ FSMLL 51_ EQNDL 56_ EPGHT 61_ ELLRE 66_ LLASL 71_ RRHDL 76_ LRRVD 81_ DFEAG 86_ AAAGA 91_ APGEE 96_ DLCAA 101_ FNVIC 106_ DNVGK 111_ DWRRL 116_ ARQLK 121_ VSDTK 126_ IDSIE 131_ DRYPR 136_ NLTER 141_ VRESL 146_ RIWKN 151_ TEKEN 156_ ATVAH 161_ LVGAL 166_ RSCQM 171_ NLVAD 176_ LVQEV 181_ QQARD 186_ LQNRS 191_ GAMSP 196_ MSWNS 201_DASTS
1: Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:23955153, PubMed:24025841, PubMed:7538907, PubMed:9184224). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:7538907, PubMed:9184224). Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225, PubMed:24204270)