Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4)
1_MEALP 6_ LLAAT 11_ TPDHG 16_ RHRRL 21_ LLLPL 26_ LLFLL 31_ PAGAV 36_ QGWET 41_ EERPR 46_ TREEE 51_ CHFYA 56_ GGQVY 61_ PGEAS 66_ RVSVA 71_ DHSLH 76_ LSKAK 81_ ISKPA 86_ PYWEG 91_ TAVID 96_ GEFKE 101_ LKLTD 106_ YRGKY 111_ LVFFF 116_ YPLDF 121_ TFVCP 126_ TEIIA 131_ FGDRL 136_ EEFRS 141_ INTEV 146_ VACSV 151_ DSQFT 156_ HLAWI 161_ NTPRR 166_ QGGLG 171_ PIRIP 176_ LLSDL 181_ THQIS 186_ KDYGV 191_ YLEDS 196_ GHTLR 201_ GLFII 206_ DDKGI 211_ LRQIT 216_ LNDLP 221_ VGRSV 226_ DETLR 231_ LVQAF 236_ QYTDK 241_ HGEVC 246_ PAGWK 251_ PGSET 256_ IIPDP 261_ AGKLK 266_YFDKL
1: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation