Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
1_MLWLA 6_ LGPFP 11_ AMENQ 16_ VLVIR 21_ IKIPN 26_ SGAVD 31_ WTVHS 36_ GPQLL 41_ FRDVL 46_ DVIGQ 51_ VLPEA 56_ TTTAF 61_ EYEDE 66_ DGDRI 71_ TVRSD 76_ EEMKA 81_ MLSYY 86_ YSTVM 91_ EQQVN 96_ GQLIE 101_ PLQIF 106_ PRACK 111_ PPGER 116_ NIHGL 121_ KVNTR 126_ AGPSQ 131_ HSSPA 136_ VSDSL 141_ PSNSL 146_ KKSSA 151_ ELKKI 156_ LANGQ 161_ MNEQD 166_ IRYRD 171_ TLGHG 176_ NGGTV 181_ YKAYH 186_ VPSGK 191_ ILAVK 196_ VILLD 201_ ITLEL 206_ QKQIM 211_ SELEI 216_ LYKCD 221_ SSYII 226_ GFYGA 231_ FFVEN 236_ RISIC 241_ TEFMD 246_ GGSLD 251_ VYRKM 256_ PEHVL 261_ GRIAV 266_ AVVKG 271_ LTYLW 276_ SLKIL 281_ HRDVK 286_ PSNML 291_ VNTRG 296_ QVKLC 301_ DFGVS 306_ TQLVN 311_ SIAKT 316_ YVGTN 321_ AYMAP 326_ ERISG 331_ EQYGI 336_ HSDVW 341_ SLGIS 346_ FMELA 351_ LGRFP 356_ YPQIQ 361_ KNQGS 366_ LMPLQ 371_ LLQCI 376_ VDEDS 381_ PVLPV 386_ GEFSE 391_ PFVHF 396_ ITQCM 401_ RKQPK 406_ ERPAP 411_ EELMG 416_ HPFIV 421_ QFNDG 426_ NAAVV 431_ SMWVC 436_ RALEE 441_RRSQQ
1: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)