Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)
1_MATCW 6_ QALWA 11_ YRSYL 16_ IVFFV 21_ PILLL 26_ PLPIL 31_ VPSKE 36_ AYCAY 41_ AIILM 46_ ALFWC 51_ TEALP 56_ LAVTA 61_ LFPLI 66_ LFPMM 71_ GIVDA 76_ SEVAV 81_ EYLKD 86_ SNLLF 91_ FGGLL 96_ VAIAV 101_ EHWNL 106_ HKRIA 111_ LRVLL 116_ IVGVR 121_ PAPLI 126_ LGFML 131_ VTAFL 136_ SMWIS 141_ NTATS 146_ AMMVP 151_ IAHAV 156_ LDQLH 161_ SSQAS 166_ SNVEE 171_ GSNNP 176_ TFELQ 181_ EPSPQ 186_ KEVTK 191_ LDNGQ 196_ ALPVT 201_ SASSE 206_ GRAHL 211_ SQKHL 216_ HLTQC 221_ MSLCV 226_ CYSAS 231_ IGGIA 236_ TLTGT 241_ APNLV 246_ LQGQI 251_ NSLFP 256_ QNGNV 261_ VNFAS 266_ WFSFA 271_ FPTMV 276_ ILLLL 281_ AWLWL 286_ QILFL 291_ GFNFR 296_ KNFGI 301_ GEKMQ 306_ EQQQA 311_ AYCVI 316_ QTEHR 321_ LLGPM 326_ TFAEK 331_ AISIL 336_ FVILV 341_ LLWFT 346_ REPGF 351_ FLGWG 356_ NLAFP 361_ NAKGE 366_ SMVSD 371_ GTVAI 376_ FIGII 381_ MFIIP 386_ SKFPG 391_ LTQDP 396_ ENPGK 401_ LKAPL 406_ GLLDW 411_ KTVNQ 416_ KMPWN 421_ IVLLL 426_ GGGYA 431_ LAKGS 436_ ERSGL 441_ SEWLG 446_ NKLTP 451_ LQSVP 456_ APAIA 461_ IILSL 466_ LVATF 471_ TECTS 476_ NVATT 481_ TIFLP 486_ ILASM 491_ AQAIC 496_ LHPLY 501_ VMLPC 506_ TLATS 511_ LAFML 516_ PVATP 521_ PNAIV 526_ FSFGD 531_ LKVLD 536_ MARAG 541_ FLLNI 546_ IGVLI 551_ IALAI 556_ NSWGI 561_ PLFSL 566_ HSFPS 571_ WAQSN 576_ TTAQC 581_ LPSLA 586_NTTTP
1: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:8967342, PubMed:9668069). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10894787, PubMed:8967342, PubMed:9668069). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity)