Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
1_MASNK 6_ TTLQK 11_ MGKKQ 16_ NGKSK 21_ KVEEA 26_ EPEEF 31_ VVEKV 36_ LDRRV 41_ VNGKV 46_ EYFLK 51_ WKGFT 56_ DADNT 61_ WEPEE 66_ NLDCP 71_ ELIEA 76_ FLNSQ 81_ KAGKE 86_ KDGTK 91_ RKSLS 96_ DSESD 101_ DSKSK 106_ KKRDA 111_ ADKPR 116_ GFARG 121_ LDPER 126_ IIGAT 131_ DSSGE 136_ LMFLM 141_ KWKDS 146_ DEADL 151_ VLAKE 156_ ANMKC 161_ PQIVI 166_ AFYEE 171_ RLTWH 176_SCPED
1: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679)