Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
1_MEQPP 6_ APKSK 11_ LKKLS 16_ EDSLT 21_ KQPEE 26_ VFDVL 31_ EKLGE 36_ GSYGS 41_ VFKAI 46_ HKESG 51_ QVVAI 56_ KQVPV 61_ ESDLQ 66_ EIIKE 71_ ISIMQ 76_ QCDSP 81_ YVVKY 86_ YGSYF 91_ KNTDL 96_ WIVME 101_ YCGAG 106_ SVSDI 111_ IRLRN 116_ KTLIE 121_ DEIAT 126_ ILKST 131_ LKGLE 136_ YLHFM 141_ RKIHR 146_ DIKAG 151_ NILLN 156_ TEGHA 161_ KLADF 166_ GVAGQ 171_ LTDTM 176_ AKRNT 181_ VIGTP 186_ FWMAP 191_ EVIQE 196_ IGYNC 201_ VADIW 206_ SLGIT 211_ SIEMA 216_ EGKPP 221_ YADIH 226_ PMRAI 231_ FMIPT 236_ NPPPT 241_ FRKPE 246_ LWSDD 251_ FTDFV 256_ KKCLV 261_ KNPEQ 266_ RATAT 271_ QLLQH 276_ PFIKN 281_ AKPVS 286_ ILRDL 291_ ITEAM 296_ EIKAK 301_ RHEEQ 306_ QRELE 311_ EEEEN 316_ SDEDE 321_ LDSHT 326_ MVKTS 331_ VESVG 336_ TMRAT 341_ STMSE 346_ GAQTM 351_ IEHNS 356_ TMLES 361_ DLGTM 366_ VINSE 371_ DEEEE 376_ DGTMK 381_ RNATS 386_ PQVQR 391_ PSFMD 396_ YFDKQ 401_ DFKNK 406_ SHENC 411_ NQNMH 416_ EPFPM 421_ SKNVF 426_ PDNWK 431_ VPQDG 436_ DFDFL 441_ KNLSL 446_ EELQM 451_ RLKAL 456_ DPMME 461_ REIEE 466_ LRQRY 471_ TAKRQ 476_ PILDA 481_ MDAKK 486_RRQQN
1: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890)