E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
1_MANSM 6_ NGRNP 11_ GGRGG 16_ NPRKG 21_ RILGI 26_ IDAIQ 31_ DAVGP 36_ PKQAA 41_ ADRRT 46_ VEKTW 51_ KLMDK 56_ VVRLC 61_ QNPKL 66_ QLKNS 71_ PPYIL 76_ DILPD 81_ TYQHL 86_ RLILS 91_ KYDDN 96_ QKLAQ 101_ LSENE 106_ YFKIY 111_ IDSLM 116_ KKSKR 121_ AIRLF 126_ KEGKE 131_ RMYEE 136_ QSQDR 141_ RNLTK 146_ LSLIF 151_ SHMLA 156_ EIKAI 161_ FPNGQ 166_ FQGDN 171_ FRITK 176_ ADAAE 181_ FWRKF 186_ FGDKT 191_ IVPWK 196_ VFRQC 201_ LHEVH 206_ QISSG 211_ LEAMA 216_ LKSTI 221_ DLTCN 226_ DYISV 231_ FEFDI 236_ FTRLF 241_ QPWGS 246_ ILRNW 251_ NFLAV 256_ THPGY 261_ MAFLT 266_ YDEVK 271_ ARLQK 276_ YSTKP 281_ GSYIF 286_ RLSCT 291_ RLGQW 296_ AIGYV 301_ TGDGN 306_ ILQTI 311_ PHNKP 316_ LFQAL 321_ IDGSR 326_ EGFYL 331_ YPDGR 336_ SYNPD 341_ LTGLC 346_ EPTPH 351_ DHIKV 356_ TQEQY 361_ ELYCE 366_ MGSTF 371_ QLCKI 376_ CAEND 381_ KDVKI 386_ EPCGH 391_ LMCTS 396_ CLTAW 401_ QESDG 406_ QGCPF 411_ CRCEI 416_ KGTEP 421_ IIVDP 426_ FDPRD 431_ EGSRC 436_ CSIID 441_ PFGMP 446_ MLDLD 451_ DDDDR 456_ EESLM 461_ MNRLA 466_ NVRKC 471_ TDRQN 476_ SPVTS 481_ PGSSP 486_ LAQRR 491_ KPQPD 496_ PLQIP 501_ HLSLP 506_ PVPPR 511_ LDLIQ 516_ KGIVR 521_ SPCGS 526_ PTGSP 531_ KSSPC 536_ MVRKQ 541_ DKPLP 546_ APPPP 551_ LRDPP 556_ PPPPE 561_ RPPPI 566_ PPDNR 571_ LSRHI 576_ HHVES 581_ VPSRD 586_ PPMPL 591_ EAWCP 596_ RDVFG 601_ TNQLV 606_ GCRLL 611_ GEGSP 616_ KPGIT 621_ ASSNV 626_ NGRHS 631_ RVGSD 636_ PVLMR 641_ KHRRH 646_ DLPLE 651_ GAKVF 656_ SNGHL 661_ GSEEY 666_ DVPPR 671_ LSPPP 676_ PVTTL 681_ LPSIK 686_ CTGPL 691_ ANSLS 696_ EKTRD 701_ PVEED 706_ DDEYK 711_ IPSSH 716_ PVSLN 721_ SQPSH 726_ CHNVK 731_ PPVRS 736_ CDNGH 741_ CMLNG 746_ THGPS 751_ SEKKS 756_ NIPDL 761_ SIYLK 766_ GDVFD 771_ SASDP 776_ VPLPP 781_ ARPPT 786_ RDNPK 791_ HGSSL 796_ NRTPS 801_ DYDLL 806_ IPPLG 811_ EDAFD 816_ ALPPS 821_ LPPPP 826_ PPARH 831_ SLIEH 836_ SKPPG 841_ SSSRP 846_ SSGQD 851_ LFLLP 856_ SDPFV 861_ DLASG 866_ QVPLP 871_ PARRL 876_ PGENV 881_ KTNRT 886_ SQDYD 891_ QLPSC 896_ SDGSQ 901_ APARP 906_ PKPRP 911_ RRTAP 916_ EIHHR 921_ KPHGP 926_ EAALE 931_ NVDAK 936_ IAKLM 941_ GEGYA 946_ FEEVK 951_ RALEI 956_ AQNNV 961_ EVARS 966_ ILREF 971_ AFPPP 976_VSPRL
1: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)