Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5)
1_MAGDR 6_ LPRKV 11_ MDAKK 16_ LASLL 21_ RGGPG 26_ GPLVI 31_ DSRSF 36_ VEYNS 41_ WHVLS 46_ SVNIC 51_ CSKLV 56_ KRRLQ 61_ QGKVT 66_ IAELI 71_ QPAAR 76_ SQVEA 81_ TEPQD 86_ VVVYD 91_ QSTRD 96_ ASVLA 101_ ADSFL 106_ SILLS 111_ KLDGC 116_ FDSVA 121_ ILTGG 126_ FATFS 131_ SCFPG 136_ LCEGK 141_ PAALL 146_ PMSLS 151_ QPCLP 156_ VPSVG 161_ LTRIL 166_ PHLYL 171_ GSQKD 176_ VLNKD 181_ LMTQN 186_ GISYV 191_ LNASN 196_ SCPKP 201_ DFICE 206_ SRFMR 211_ VPIND 216_ NYCEK 221_ LLPWL 226_ DKSIE 231_ FIDKA 236_ KLSSC 241_ QVIVH 246_ CLAGI 251_ SRSAT 256_ IAIAY 261_ IMKTM 266_ GMSSD 271_ DAYRF 276_ VKDRR 281_ PSISP 286_ NFNFL 291_ GQLLE 296_ YERSL 301_ KLLAA 306_ LQGDP 311_ GTPSG 316_ TPEPP 321_ PSPAA 326_ GAPLP 331_ RLPPP 336_ TSESA 341_ ATGNA 346_ AAREG 351_ GLSAG 356_ GEPPA 361_ PPTPP 366_ ATSAL 371_ QQGLR 376_ GLHLS 381_ SDRLQ 386_ DTNRL 391_ KRSFS 396_ LDIKS 401_ AYAPS 406_ RRPDG 411_ PGPPD 416_ PGEAP 421_ KLCKL 426_ DSPSG 431_ AALGL 436_ SSPSP 441_ DSPDA 446_ APEAR 451_ PRPRR 456_ RPRPP 461_ AGSPA 466_ RSPAH 471_ SLGLN 476_ FGDAA 481_ RQTPR 486_ HGLSA 491_ LSAPG 496_ LPGPG 501_ QPAGP 506_ GAWAP 511_ PLDSP 516_ GTPSP 521_ DGPWC 526_ FSPEG 531_ AQGAG 536_ GVLFA 541_ PFGRA 546_ GAPGP 551_ GGGSD 556_ LRRRE 561_ AARAE 566_ PRDAR 571_ TGWPE 576_ EPAPE 581_ TQFKR 586_ RSCQM 591_ EFEEG 596_ MVEGR 601_ ARGEE 606_ LAALG 611_ KQASF 616_SGSVE
1: Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues