T-box transcription factor TBX2 (T-box protein 2)
1_MREPA 6_ LAASA 11_ MAYHP 16_ FHAPR 21_ PADFP 26_ MSAFL 31_ AAAQP 36_ SFFPA 41_ LALPP 46_ GALAK 51_ PLPDP 56_ GLAGA 61_ AAAAA 66_ AAAAA 71_ AEAGL 76_ HVSAL 81_ GPHPP 86_ AAHLR 91_ SLKSL 96_ EPEDE 101_ VEDDP 106_ KVTLE 111_ AKELW 116_ DQFHK 121_ LGTEM 126_ VITKS 131_ GRRMF 136_ PPFKV 141_ RVSGL 146_ DKKAK 151_ YILLM 156_ DIVAA 161_ DDCRY 166_ KFHNS 171_ RWMVA 176_ GKADP 181_ EMPKR 186_ MYIHP 191_ DSPAT 196_ GEQWM 201_ AKPVA 206_ FHKLK 211_ LTNNI 216_ SDKHG 221_ FTILN 226_ SMHKY 231_ QPRFH 236_ IVRAN 241_ DILKL 246_ PYSTF 251_ RTYVF 256_ PETDF 261_ IAVTA 266_ YQNDK 271_ ITQLK 276_ IDNNP 281_ FAKGF 286_ RDTGN 291_ GRREK 296_ RKQLT 301_ LPSLR 306_ LYEEH 311_ CKPER 316_ DGAES 321_ DASSC 326_ DPPPA 331_ REPPT 336_ SPGAA 341_ PSPLR 346_ LHRAR 351_ AEEKS 356_ CAADS 361_ DPEPE 366_ RLSEE 371_ RAGAP 376_ LGRSP 381_ APDSA 386_ SPTRL 391_ TEPER 396_ ARERR 401_ SPERG 406_ KEPAE 411_ SGGDG 416_ PFGLR 421_ SLEKE 426_ RAEAR 431_ RKDEG 436_ RKEAA 441_ EGKEQ 446_ GLAPL 451_ VVQTD 456_ SASPL 461_ GAGHL 466_ PGLAF 471_ SSHLH 476_ GQQFF 481_ GPLGA 486_ GQPLF 491_ LHPGQ 496_ FTMGP 501_ GAFSA 506_ MGMGH 511_ LLASV 516_ AGGGN 521_ GGGGG 526_ PGTAA 531_ GLDAG 536_ GLGPA 541_ ASAAS 546_ TAAPF 551_ PFHLS 556_ QHMLA 561_ SQGIP 566_ MPTFG 571_ GLFPY 576_ PYTYM 581_ AAAAA 586_ AASAL 591_ PATSA 596_ AAAAA 601_ AAAGS 606_ LSRSP 611_ FLGSA 616_ RPRLR 621_ FSPYQ 626_ IPVTI 631_ PPSTS 636_ LLTTG 641_ LASEG 646_ SKAAG 651_ GNSRE 656_ PSPLP 661_ ELALR 666_ KVGAP 671_ SRGAL 676_ SPSGS 681_ AKEAA 686_ NELQS 691_ IQRLV 696_ SGLES 701_ QRALS 706_PGRES
1: Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203)