DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)
1_MVAPG 6_ SVTSR 11_ LGSVF 16_ PFLLV 21_ LVDLQ 26_ YEGAE 31_ CGVNA 36_ DVEKH 41_ LELGK 46_ KLLAA 51_ GQLAD 56_ ALSQF 61_ HAAVD 66_ GDPDN 71_ YIAYY 76_ RRATV 81_ FLAMG 86_ KSKAA 91_ LPDLT 96_ KVIQL 101_ KMDFT 106_ AARLQ 111_ RGHLL 116_ LKQGK 121_ LDEAE 126_ DDFKK 131_ VLKSN 136_ PSENE 141_ EKEAQ 146_ SQLIK 151_ SDEMQ 156_ RLRSQ 161_ ALNAF 166_ GSGDY 171_ TAAIA 176_ FLDKI 181_ LEVCV 186_ WDAEL 191_ RELRA 196_ ECFIK 201_ EGEPR 206_ KAISD 211_ LKAAS 216_ KLKND 221_ NTEAF 226_ YKIST 231_ LYYQL 236_ GDHEL 241_ SLSEV 246_ RECLK 251_ LDQDH 256_ KRCFA 261_ HYKQV 266_ KKLNK 271_ LIESA 276_ EELIR 281_ DGRYT 286_ DATSK 291_ YESVM 296_ KTEPS 301_ IAEYT 306_ VRSKE 311_ RICHC 316_ FSKDE 321_ KPVEA 326_ IRVCS 331_ EVLQM 336_ EPDNV 341_ NALKD 346_ RAEAY 351_ LIEEM 356_ YDEAI 361_ QDYET 366_ AQEHN 371_ ENDQQ 376_ IREGL 381_ EKAQR 386_ LLKQS 391_ QKRDY 396_ YKILG 401_ VKRNA 406_ KKQEI 411_ IKAYR 416_ KLALQ 421_ WHPDN 426_ FQNEE 431_ EKKKA 436_ EKKFI 441_ DIAAA 446_ KEVLS 451_ DPEMR 456_ KKFDD 461_ GEDPL 466_ DAESQ 471_ QGGGG 476_ NPFHR 481_ SWNSW 486_ QGFNP 491_ FSSGG 496_PFRFK
1: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity