Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
1_MRLWS 6_ WVLHL 11_ GLLSA 16_ ALGCG 21_ LAERP 26_ RRARR 31_ DPRAG 36_ RPPRP 41_ AAGPA 46_ TCATR 51_ AARGR 56_ RASPP 61_ PPPPP 66_ GGAWE 71_ AVRVP 76_ RRRQQ 81_ REARG 86_ ATEEP 91_ SPPSR 96_ ALYFS 101_ GRGEQ 106_ LRLRA 111_ DLELP 116_ RDAFT 121_ LQVWL 126_ RAEGG 131_ QRSPA 136_ VITGL 141_ YDKCS 146_ YISRD 151_ RGWVV 156_ GIHTI 161_ SDQDN 166_ KDPRY 171_ FFSLK 176_ TDRAR 181_ QVTTI 186_ NAHRS 191_ YLPGQ 196_ WVYLA 201_ ATYDG 206_ QFMKL 211_ YVNGA 216_ QVATS 221_ GEQVG 226_ GIFSP 231_ LTQKC 236_ KVLML 241_ GGSAL 246_ NHNYR 251_ GYIEH 256_ FSLWK 261_ VARTQ 266_ REILS 271_ DMETH 276_ GAHTA 281_ LPQLL 286_ LQENW 291_ DNVKH 296_ AWSPM 301_ KDGSS 306_ PKVEF 311_ SNAHG 316_ FLLDT 321_ SLEPP 326_ LCGQT 331_ LCDNT 336_ EVIAS 341_ YNQLS 346_ SFRQP 351_ KVVRY 356_ RVVNL 361_ YEDDH 366_ KNPTV 371_ TREQV 376_ DFQHH 381_ QLAEA 386_ FKQYN 391_ ISWEL 396_ DVLEV 401_ SNSSL 406_ RRRLI 411_ LANCD 416_ ISKIG 421_ DENCD 426_ PECNH 431_ TLTGH 436_ DGGDC 441_ RHLRH 446_ PAFVK 451_ KQHNG 456_ VCDMD 461_ CNYER 466_ FNFDG 471_ GECCD 476_ PEITN 481_ VTQTC 486_ FDPDS 491_ PHRAY 496_ LDVNE 501_ LKNIL 506_ KLDGS 511_ THLNI 516_ FFAKS 521_ SEEEL 526_ AGVAT 531_ WPWDK 536_ EALMH 541_ LGGIV 546_ LNPSF 551_ YGMPG 556_ HTHTM 561_ IHEIG 566_ HSLGL 571_ YHVFR 576_ GISEI 581_ QSCSD 586_ PCMET 591_ EPSFE 596_ TGDLC 601_ NDTNP 606_ APKHK 611_ SCGDP 616_ GPGND 621_ TCGFH 626_ SFFNT 631_ PYNNF 636_ MSYAD 641_ DDCTD 646_ SFTPN 651_ QVARM 656_ HCYLD 661_ LVYQG 666_ WQPSR 671_ KPAPV 676_ ALAPQ 681_ VLGHT 686_ TDSVT 691_ LEWFP 696_ PIDGH 701_ FFERE 706_ LGSAC 711_ HLCLE 716_ GRILV 721_ QYASN 726_ ASSPM 731_ PCSPS 736_ GHWSP 741_ REAEG 746_ HPDVE 751_ QPCKS 756_ SVRTW 761_ SPNSA 766_ VNPHT 771_ VPPAC 776_ PEPQG 781_ CYLEL 786_ EFLYP 791_ LVPES 796_ LTIWV 801_ TFVST 806_ DWDSS 811_ GAVND 816_ IKLLA 821_ VSGKN 826_ ISLGP 831_ QNVFC 836_ DVPLT 841_ IRLWD 846_ VGEEV 851_ YGIQI 856_ YTLDE 861_ HLEID 866_ AAMLT 871_ STADT 876_ PLCLQ 881_ CKPLK 886_ YKVVR 891_ DPPLQ 896_ MDVAS 901_ ILHLN 906_ RKFVD 911_ MDLNL 916_ GSVYQ 921_ YWVIT 926_ ISGTE 931_ ESEPS 936_ PAVTY 941_ IHGSG 946_ YCGDG 951_ IIQKD 956_ QGEQC 961_ DDMNK 966_ INGDG 971_ CSLFC 976_ RQEVS 981_ FNCID 986_ EPSRC 991_ YFHDG 996_ DGVCE 1001_ EFEQK 1006_ TSIKD 1011_ CGVYT 1016_ PQGFL 1021_ DQWAS 1026_ NASVS 1031_ HQDQQ 1036_ CPGWV 1041_ IIGQP 1046_ AASQV 1051_ CRTKV 1056_ IDLSE 1061_ GISQH 1066_ AWYPC 1071_ TISYP 1076_ YSQLA 1081_ QTTFW 1086_ LRAYF 1091_ SQPMV 1096_ AAAVI 1101_ VHLVT 1106_ DGTYY 1111_ GDQKQ 1116_ ETISV 1121_ QLLDT 1126_ KDQSH 1131_ DLGLH 1136_ VLSCR 1141_ NNPLI 1146_ IPVVH 1151_ DLSQP 1156_ FYHSQ 1161_ AVRVS 1166_ FSSPL 1171_ VAISG 1176_ VALRS 1181_ FDNFD 1186_ PVTLS 1191_ SCQRG 1196_ ETYSP 1201_ AEQSC 1206_ VHFAC 1211_ EKTDC 1216_ PELAV 1221_ ENASL 1226_ NCSSS 1231_ DRYHG 1236_ AQCTV 1241_ SCRTG 1246_ YVLQI 1251_ RRDDE 1256_ LIKSQ 1261_ TGPSV 1266_ TVTCT 1271_ EGKWN 1276_ KQVAC 1281_ EPVDC 1286_ SIPDH 1291_ HQVYA 1296_ ASFSC 1301_ PEGTT 1306_ FGSQC 1311_ SFQCR 1316_ HPAQL 1321_ KGNNS 1326_ LLTCM 1331_ EDGLW 1336_ SFPEA 1341_ LCELM 1346_ CLAPP 1351_ PVPNA 1356_ DLQTA 1361_ RCREN 1366_ KHKVG 1371_ SFCKY 1376_ KCKPG 1381_ YHVPG 1386_ SSRKS 1391_ KKRAF 1396_ KTQCT 1401_ QDGSW 1406_ QEGAC 1411_ VPVTC 1416_ DPPPP 1421_ KFHGL 1426_ YQCTN 1431_ GFQFN 1436_ SECRI 1441_ KCEDS 1446_ DASQG 1451_ LGSNV 1456_ IHCRK 1461_ DGTWN 1466_ GSFHV 1471_ CQEMQ 1476_ GQCSV 1481_ PNELN 1486_ SNLKL 1491_ QCPDG 1496_ YAIGS 1501_ ECATS 1506_ CLDHN 1511_ SESII 1516_ LPMNV 1521_ TVRDI 1526_ PHWLN 1531_ PTRVE 1536_ RVVCT 1541_ AGLKW 1546_ YPHPA 1551_ LIHCV 1556_ KGCEP 1561_ FMGDN 1566_ YCDAI 1571_ NNRAF 1576_ CNYDG 1581_ GDCCT 1586_ STVKT 1591_ KKVTP 1596_ FPMSC 1601_ DLQGD 1606_ CACRD 1611_ PQAQE 1616_ HSRKD 1621_LRGYS
1: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF