Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
1_MKPRA 6_ ECCSP 11_ KFWLV 16_ LAVLA 21_ VSGSR 26_ ARSQK 31_ SPPSI 36_ GIAVI 41_ LVGTS 46_ DEVAI 51_ KDAHE 56_ KDDFH 61_ HLSVV 66_ PRVEL 71_ VAMNE 76_ TDPKS 81_ IITRI 86_ CDLMS 91_ DRKIQ 96_ GVVFA 101_ DDTDQ 106_ EAIAQ 111_ ILDFI 116_ SAQTL 121_ TPILG 126_ IHGGS 131_ SMIMA 136_ DKDES 141_ SMFFQ 146_ FGPSI 151_ EQQAS 156_ VMLNI 161_ MEEYD 166_ WYIFS 171_ IVTTY 176_ FPGYQ 181_ DFVNK 186_ IRSTI 191_ ENSFV 196_ GWELE 201_ EVLLL 206_ DMSLD 211_ DGDSK 216_ IQNQL 221_ KKLQS 226_ PIILL 231_ YCTKE 236_ EATYI 241_ FEVAN 246_ SVGLT 251_ GYGYT 256_ WIVPS 261_ LVAGD 266_ TDTVP 271_ AEFPT 276_ GLISV 281_ SYDEW 286_ DYGLP 291_ ARVRD 296_ GIAII 301_ TTAAS 306_ DMLSE 311_ HSFIP 316_ EPKSS 321_ CYNTH 326_ EKRIY 331_ QSNML 336_ NRYLI 341_ NVTFE 346_ GRNLS 351_ FSEDG 356_ YQMHP 361_ KLVII 366_ LLNKE 371_ RKWER 376_ VGKWK 381_ DKSLQ 386_ MKYYV 391_ WPRMC 396_ PETEE 401_ QEDDH 406_ LSIVT 411_ LEEAP 416_ FVIVE 421_ SVDPL 426_ SGTCM 431_ RNTVP 436_ CQKRI 441_ VTENK 446_ TDEEP 451_ GYIKK 456_ CCKGF 461_ CIDIL 466_ KKISK 471_ SVKFT 476_ YDLYL 481_ VTNGK 486_ HGKKI 491_ NGTWN 496_ GMIGE 501_ VVMKR 506_ AYMAV 511_ GSLTI 516_ NEERS 521_ EVVDF 526_ SVPFI 531_ ETGIS 536_ VMVSR 541_ SNGTV 546_ SPSAF 551_ LEPFS 556_ ADVWV 561_ MMFVM 566_ LLIVS 571_ AVAVF 576_ VFEYF 581_ SPVGY 586_ NRCLA 591_ DGREP 596_ GGPSF 601_ TIGKA 606_ IWLLW 611_ GLVFN 616_ NSVPV 621_ QNPKG 626_ TTSKI 631_ MVSVW 636_ AFFAV 641_ IFLAS 646_ YTANL 651_ AAFMI 656_ QEEYV 661_ DQVSG 666_ LSDKK 671_ FQRPN 676_ DFSPP 681_ FRFGT 686_ VPNGS 691_ TERNI 696_ RNNYA 701_ EMHAY 706_ MGKFN 711_ QRGVD 716_ DALLS 721_ LKTGK 726_ LDAFI 731_ YDAAV 736_ LNYMA 741_ GRDEG 746_ CKLVT 751_ IGSGK 756_ VFAST 761_ GYGIA 766_ IQKDS 771_ GWKRQ 776_ VDLAI 781_ LQLFG 786_ DGEME 791_ ELEAL 796_ WLTGI 801_ CHNEK 806_ NEVMS 811_ SQLDI 816_ DNMAG 821_ VFYML 826_ GAAMA 831_ LSLIT 836_ FICEH 841_ LFYWQ 846_ FRHCF 851_ MGVCS 856_ GKPGM 861_ VFSIS 866_ RGIYS 871_ CIHGV 876_ AIEER 881_ QSVMN 886_ SPTAT 891_ MNNTH 896_ SNILR 901_ LLRTA 906_ KNMAN 911_ LSGVN 916_ GSPQS 921_ ALDFI 926_ RRESS 931_ VYDIS 936_ EHRRS 941_ FTHSD 946_ CKSYN 951_ NPPCE 956_ ENLFS 961_ DYISE 966_ VERTF 971_ GNLQL 976_ KDSNV 981_ YQDHY 986_ HHHHR 991_ PHSIG 996_ SASSI 1001_ DGLYD 1006_ CDNPP 1011_ FTTQS 1016_ RSISK 1021_ KPLDI 1026_ GLPSS 1031_ KHSQL 1036_ SDLYG 1041_ KFSFK 1046_ SDRYS 1051_ GHDDL 1056_ IRSDV 1061_ SDIST 1066_ HTVTY 1071_ GNIEG 1076_ NAAKR 1081_ RKQQY 1086_ KDSLK 1091_ KRPAS 1096_ AKSRR 1101_ EFDEI 1106_ ELAYR 1111_ RRPPR 1116_ SPDHK 1121_ RYFRD 1126_ KEGLR 1131_ DFYLD 1136_ QFRTK 1141_ ENSPH 1146_ WEHVD 1151_ LTDIY 1156_ KERSD 1161_ DFKRD 1166_ SVSGG 1171_ GPCTN 1176_ RSHIK 1181_ HGTGD 1186_ KHGVV 1191_ SGVPA 1196_ PWEKN 1201_ LTNVE 1206_ WEDRS 1211_ GGNFC 1216_ RSCPS 1221_ KLHNY 1226_ STTVT 1231_ GQNSG 1236_ RQACI 1241_ RCEAC 1246_ KKAGN 1251_ LYDIS 1256_ EDNSL 1261_ QELDQ 1266_ PAAPV 1271_ AVTSN 1276_ ASTTK 1281_ YPQSP 1286_ TNSKA 1291_ QKKNR 1296_ NKLRR 1301_ QHSYD 1306_ TFVDL 1311_ QKEEA 1316_ ALAPR 1321_ SVSLK 1326_ DKGRF 1331_ MDGSP 1336_ YAHMF 1341_ EMSAG 1346_ ESTFA 1351_ NNKSS 1356_ VPTAG 1361_ HHHHN 1366_ NPGGG 1371_ YMLSK 1376_ SLYPD 1381_ RVTQN 1386_ PFIPT 1391_ FGDDQ 1396_ CLLHG 1401_ SKSYF 1406_ FRQPT 1411_ VAGAS 1416_ KARPD 1421_ FRALV 1426_ TNKPV 1431_ VSALH 1436_ GAVPA 1441_ RFQKD 1446_ ICIGN 1451_ QSNPC 1456_ VPNNK 1461_ NPRAF 1466_ NGSSN 1471_ GHVYE 1476_KLSSI
1: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity)