G protein pathway suppressor 2 (GPS-2)
1_MPALL 6_ ERPKL 11_ SNAMA 16_ RALHR 21_ HIMME 26_ RERKR 31_ QEEEE 36_ VDKMM 41_ EQKMK 46_ EEQER 51_ RKKKE 56_ MEERM 61_ SLEET 66_ KEQIL 71_ KLEEK 76_ LLALQ 81_ EEKHQ 86_ LFLQL 91_ KKVLH 96_ EEEKR 101_ RRKEQ 106_ SDLTT 111_ LTSAA 116_ YQQSL 121_ TVHTG 126_ THLLS 131_ MQGSP 136_ GGHNR 141_ PGTLM 146_ AADRA 151_ KQMFG 156_ PQVLT 161_ TRHYV 166_ GSAAA 171_ FAGTP 176_ EHGQF 181_ QGSPG 186_ GAYGT 191_ AQPPP 196_ HYGPT 201_ QPAYS 206_ PSQQL 211_ RAPSA 216_ FPAVQ 221_ YLSQP 226_ QPQPY 231_ AVHGH 236_ FQPTQ 241_ TGFLQ 246_ PGGAL 251_ SLQKQ 256_ MEHAN 261_ QQTGF 266_ SDSSS 271_ LRPMH 276_ PQALH 281_ PAPGL 286_ LASPQ 291_ LPVQM 296_ QPAGK 301_ SGFAA 306_ TSQPG 311_ PRLPF 316_ IQHSQ 321_NPRFY
1: Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081)
2: (Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A